Antibody to HTLV-I in Indigenous Inhabitants of the Andes and Amazon Regions in Colombia
| Autor: | Vladimir Zaninovic, Masanori Hayami, Haruko Komoda, Masaharu Kajiwara, Kazuo Tajima, Tomás Omar Zamora |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Rural Population Cancer Research viruses Colombia Indigenous immune system diseases Particle agglutination Humans South American Indian High titre Human T-lymphotropic virus 1 Deltaretrovirus Infections HTLV‐I‐associated myelopathy HTLV‐I South American Indians biology Deltaretrovirus Antibodies Amazon rainforest Indians South American Carrier state Tropical spastic paraparesis virus diseases Emigration and Immigration Middle Aged Virology Geography Oncology Carrier State biology.protein Htlv i associated myelopathy Female Antibody Rapid Communication |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| Popis: | To explore the HTLV-I-carrying groups among the indigenous inhabitants in South America, a sero-epidemiological study on HTLV-I focusing on hinterland villages isolated from others in the Andes and Amazon regions was conducted. Five (2.9%) out of 171 subjects showed positive for HTLV-I antibody in the gelatin particle agglutination (PA) test. Two out of 5 positives with high antibody titer (greater than or equal to x 1024) in the PA test also showed a positive immunofluorescence (IF) test and anti-HTLV-I-specific protein products, p19, p24, p28, gp46, and p53 in sera by the Western blotting (WB) test. One of three negatives in the IF test showed positive antibodies to p19 and p24 by the WB test. Finally, two were confirmed as HTLV-I carriers and one was suspected of being a carrier. All three are Paez Indians from the central Andes; 53- and 34-year-old women and a 35-year-old man. The results show that HTLV-I carriers exist among isolated indigenous people in South America. |
| Databáze: | OpenAIRE |
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