Could cisplatin as a front-line treatment in childhood non-Hodgkin's lymphoma be a promising therapy?
| Autor: | C. Van Vliet-Constantinidou, M. Moschovi, D. Anagnostou-Keramida, F. Tzortzatou-Stathopoulou, M. Panagopoulou-Cristaki, Alexandra Papadopoulou, A. Botsonis, George Th. Tsangaris |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Oncology
Male medicine.medical_specialty Vincristine Cyclophosphamide Adolescent medicine.medical_treatment immune system diseases Bone Marrow hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Child Anaplastic large-cell lymphoma Chemotherapy business.industry Lymphoma Non-Hodgkin Hematology medicine.disease Surgery Lymphoma Non-Hodgkin's lymphoma Regimen Child Preschool Pediatrics Perinatology and Child Health Female Sarcoma Cisplatin business medicine.drug |
| Zdroj: | Pediatric hematology and oncology. 16(4) |
| ISSN: | 0888-0018 |
| Popis: | Non-Hodgkin's lymphomas (NHL) were often erroneously diagnosed as other malignancies and treated accordingly. In this study cisplatin combined with vincristine, cyclophosphamide, and Adriamycin was used incidentally as a front-line treatment in seven children with NHL, because the initial histologic diagnosis was that of a sarcoma. After reevaluation three patients had Ki-1 anaplastic large cell lymphoma of T-cell origin, two abdominal B-cell diffuse high-grade NHL, one mediastinal diffuse large B-cell lymphoma, and one B-cell lymphoma in the stomach. They received at least two courses of cisplatin combined regimen and continued with other protocols for NHL. All patients showed an extremely good response from the first course of therapy and the masses vanished completely. They were followed up for a mean time of 29.5 months and are all in complete remission. The data indicate that cisplatin is active against NHL and might be a promising alternative front-line therapy. |
| Databáze: | OpenAIRE |
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