Effects of Different Volatile Anesthetics on Cytokine and Chemokine Production After Ischemia-Reperfusion Injury in Patients Undergoing Living-Donor Kidney Transplant
| Autor: | Kamil Mehmet Tugrul, Meltem Savran Karadeniz, Ismet Nane, Aydin Turkmen, Tayfun Oktar, Hayriye Şentürk Çiftçi, Tzevat Tefik, Fatma Oguz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Turkey Renal function 030230 surgery Gastroenterology Sevoflurane Proinflammatory cytokine 03 medical and health sciences chemistry.chemical_compound Desflurane Young Adult 0302 clinical medicine Risk Factors Internal medicine medicine Living Donors Humans Prospective Studies Transplantation Creatinine business.industry Graft Survival Interleukin Middle Aged medicine.disease Kidney Transplantation Treatment Outcome chemistry Reperfusion Injury Anesthetic Anesthetics Inhalation Cytokines Female Inflammation Mediators Volatilization business Reperfusion injury Biomarkers medicine.drug |
| Zdroj: | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 17(Suppl 1) |
| ISSN: | 2146-8427 |
| Popis: | Objectives Renal transplant is the treatment of choice for patients with end-stage renal disease. Ischemiareperfusion damage is a major cause of early renal dysfunction during the perioperative period. Ischemic hypoxic damage increases local inflammation, leading to secretion of cytokines and chemokines. Anesthetic conditioning is a widely described strategy to attenuate ischemia-reperfusion injury. Here, we compared the effects of desflurane and sevoflurane on serum proinflammatory cytokines and urine chemokines in living-donor kidney transplant recipients. Materials and methods Eighty donor-recipient couples were included in this randomized study. Anesthesia maintenance was provided by desflurane or sevoflurane. Patient demographic characteristics, immunologic data, clinical data, and hemodynamic parameters were recorded. Tumor necrosis factor α, interleukins 2 and 8, chemokines 9 and 10, and serum creatinine levels were studied from pretransplant, posttransplant days 1 and 7, and posttransplant months 1 and 3 sample results. Estimated glomerular filtration rates were calculated. Acute rejection episodes and graft loss within 6 months posttransplant were recorded. Results Seventy donor-recipient couples completed the study. There were no significant differences in demographic, immunologic, and clinical data between desflurane and sevoflurane groups (P > .05). Tumor necrosis factor α, interleukin 2, chemokine 9, and chemokine 10 levels were similar preoperatively and on postoperative days 1 and 7 and months 1 and 3 (P > .05). Serum interleukin 8 levels were significantly higher in patients who received sevoflurane on postoperative days 1 (P = .045) and 7 (P = .037). No significant differences were detected in serum creatinine and estimated glomerular filtration rate between groups (P > .05). No graft loss occurred within 6 months posttransplant. Conclusions Although sevoflurane seemed to produce higher interleukin 8 levels posttransplant, both desflurane and sevoflurane had similar effects on posttransplant kidney function. We suggest that both agents have protective effects on ischemic-reperfusion damage in living-donor kidney transplant recipients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|