Nuclear hormone receptor functions in keratinocyte and melanocyte homeostasis, epidermal carcinogenesis and melanomagenesis
| Autor: | Arup K. Indra, Stephen Hyter |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Keratinocytes
medicine.medical_specialty Skin Neoplasms Transcription Genetic Cellular differentiation Biophysics Receptors Cytoplasmic and Nuclear Biology Melanocyte Biochemistry Article Structural Biology Internal medicine Genetics medicine Type II nuclear hormone receptor Homeostasis Humans Receptor BCC Melanoma Molecular Biology Tissue homeostasis Atopic dermatitis Cell Proliferation Skin Cell Nucleus Inflammation Regulation of gene expression integumentary system Cell Differentiation Cell Biology Signaling SCC Cell biology medicine.anatomical_structure Endocrinology Gene Expression Regulation Nuclear receptor Melanocytes Signal transduction Keratinocyte Signal Transduction |
| Zdroj: | FEBS Letters. 587:529-541 |
| ISSN: | 0014-5793 |
| Popis: | Skin homeostasis is maintained, in part, through regulation of gene expression orchestrated by type II nuclear hormone receptors in a cell and context specific manner. This group of transcriptional regulators is implicated in various cellular processes including epidermal proliferation, differentiation, permeability barrier formation, follicular cycling and inflammatory responses. Endogenous ligands for the receptors regulate actions during skin development and maintenance of tissue homeostasis. Type II nuclear receptor signaling is also important for cellular crosstalk between multiple cell types in the skin. Overall, these nuclear receptors are critical players in keratinocyte and melanocyte biology and present targets for cutaneous disease management. |
| Databáze: | OpenAIRE |
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