Spindle Cell Lipoma with Ossification Mimicking Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma: A Case Report
| Autor: | Jiro Ichikawa, Hiroki Imada, Atsushi Enomoto, Hirotaka Haro, Satoshi Kanno, Naofumi Taniguchi, Tomonori Kawasaki, Rikito Tatsuno |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Retinal Neoplasms CD34 Pathology and Forensic Medicine Atypical Lipomatous Tumor Osteogenesis Biomarkers Tumor medicine Atypia Humans biology business.industry Ossification Retinoblastoma protein Proto-Oncogene Proteins c-mdm2 Liposarcoma Lipoma medicine.disease body regions Spindle cell lipoma biology.protein Immunohistochemistry Surgery Anatomy medicine.symptom business |
| Zdroj: | International Journal of Surgical Pathology. 30:413-418 |
| ISSN: | 1940-2465 1066-8969 |
| DOI: | 10.1177/10668969211055798 |
| Popis: | Although spindle cell lipoma (SCL) is a subtype of lipoma, the characteristics of SCL are observed in both lipomatous and non-lipomatous tumors. In this article, we present a case of SCL with ossification mimicking atypical lipomatous tumors/well-differentiated liposarcomas (ALTs/WDLs). Considering the findings of magnetic resonance imaging and needle biopsy, which exhibited ALTs/WDLs, marginal resection was performed. Histopathological findings demonstrated mature adipocytes and spindle cells without atypia and no malignant osteoid tissue in the ossified region. In addition, immunohistochemistry (IHC) showed positive staining for CD34, heterogeneous retinoblastoma protein deficiency, and negative staining for mouse double minute 2 homolog (MDM2) and cyclin-dependent kinase. Fluorescence in-situ hybridization showed negative amplification of MDM2. The final diagnosis of the tumor was established using IHC as an extremely rare SCL with ossification. |
| Databáze: | OpenAIRE |
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