CYTOKINE PRODUCTION PRECEDES THE EXPANSION OF CD14+CD16+ MONOCYTES IN HUMAN SEPSIS
| Autor: | H. W. Ziegler-Heitbrock, Reinhard Andreesen, Peter Fraunberger, M. Blumenstein, P. Boekstegers, G. Fingerle-Rowson |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Time Factors CD14 medicine.medical_treatment Urinary system Lipopolysaccharide Receptors Inflammation CD16 Critical Care and Intensive Care Medicine Monocytes Sepsis medicine Humans Feces Interleukin-6 business.industry Monocyte Receptors IgG medicine.disease Phenotype medicine.anatomical_structure Cytokine Immunology Emergency Medicine Cytokines Female medicine.symptom business Body Temperature Regulation |
| Zdroj: | Shock. 8:73-75 |
| ISSN: | 1073-2322 |
| Popis: | We describe a patient with self-induced disease who presented with repeated urinary tract infection and sepsis due to intravesical and intravenous injection of feces. Sepsis occurred repeatedly such that the patient exhibited 10 bouts of fever > 40 degrees C in a single month. This bacterial challenge led to massive activation of the monocyte system with high levels of TNF-alpha, IL-6, and monocyte colony-stimulating factor (M-CSF). This cytokine response was followed by strong expansion of the novel CD14+CD16+ monocyte subset. These results suggest that cytokines induce the development of CD14+CD16+ cells in human septicemia and that CD14+CD16+ cells may serve as indicator for previous bouts of excessive inflammation. |
| Databáze: | OpenAIRE |
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