The roles of the nuclear pore complex in cellular dysfunction, aging and disease
| Autor: | Maximiliano A. D'Angelo, Stephen Sakuma |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Aging Cell Biology Disease Biology Article Cell biology Nuclear Pore Complex Proteins 03 medical and health sciences 030104 developmental biology Nucleocytoplasmic Transport Ran Immunology Nuclear Pore Humans Nucleoporin Nuclear pore Healthy aging Function (biology) Developmental Biology CAMKK2 |
| Popis: | The study of the Nuclear Pore Complex (NPC), the proteins that compose it (nucleoporins), and the nucleocytoplasmic transport that it controls have revealed an unexpected layer to pathogenic disease onset and progression. Recent advances in the study of the regulation of NPC composition and function suggest that the precise control of this structure is necessary to prevent diseases from arising or progressing. Here we discuss the role of nucleoporins in a diverse set of diseases, many of which directly or indirectly increase in occurrence and severity as we age, and often shorten the human lifespan. NPC biology has been shown to play a direct role in these diseases and therefore in the process of healthy aging. |
| Databáze: | OpenAIRE |
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