DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample
| Autor: | Joe Burrage, Chloe C. Y. Wong, Georgina Mansell, Helen L. Fisher, Radhika Kandaswamy, Eilis Hannon, Susanna Roberts, Karen Sugden, Ehsan Pishva, Jonathan Mill, Benjamin Williams, Andrea Danese, Louise Arseneault, Aisha Dahir, James R Staley |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Epigenomics Cancer Research animal structures longitudinal Adolescent Monozygotic twin Biology Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Humans Epigenetics Child Molecular Biology adversity Crime Victims Genetics DNA methylation epigenetics fungi victimization twins Twins Monozygotic Adolescence 030104 developmental biology Cross-Sectional Studies 030220 oncology & carcinogenesis Research Article Research Paper Genome-Wide Association Study |
| Zdroj: | Epigenetics article-version (VoR) Version of Record |
| ISSN: | 1559-2308 1559-2294 |
| Popis: | Accumulating evidence suggests that individuals exposed to victimization at key developmental stages may have different epigenetic fingerprints compared to those exposed to no/minimal stressful events, however results are inconclusive. This study aimed to strengthen causal inference regarding the impact of adolescent victimization on the epigenome by controlling for genetic variation, age, gender, and shared environmental exposures. We conducted longitudinal epigenome-wide association analyses (EWAS) on DNA methylation (DNAm) profiles of 118 monozygotic (MZ) twin pairs from the Environmental Risk study with and without severe adolescent victimization generated using buccal DNA collected at ages 5, 10 and 18, and the Illumina EPIC array. Additionally, we performed cross-sectional EWAS on age-18 blood and buccal DNA from the same individuals to elucidate tissue-specific signatures of severe adolescent victimization. Our analyses identified 20 suggestive differentially methylated positions (DMPs) (P |
| Databáze: | OpenAIRE |
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