Procedures for risk-stratification of lung cancer using buccal nanocytology
| Autor: | Parvathi Viswanathan, Hemant K. Roy, Vadim Backman, Hariharan Subramanian, Sergey Rozhok, M. Verleye, Jarema S. Czarnecki, Lusik Cherkezyan, Justin Derbas, Radha Iyengar |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology business.industry Operating procedures Buccal swab Cancer Buccal administration medicine.disease Article Atomic and Molecular Physics and Optics 03 medical and health sciences Light intensity 030104 developmental biology 0302 clinical medicine Specimen collection 030220 oncology & carcinogenesis Risk stratification medicine Lung cancer Intensive care medicine business Biotechnology |
| Zdroj: | Biomedical Optics Express. 7:3795 |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.7.003795 |
| Popis: | Lung cancer is the leading cause of cancer deaths in the U.S. with survival dramatically depending on stage at diagnosis. We had earlier reported that nanocytology of buccal cells can accurately risk-stratify smokers for the presence of early and late-stage lung cancer. To translate the technique into clinical practice, standardization of operating procedures is necessary to consistently yield precise and repeatable results. Here, we develop and validate simple, robust, and easily implementable procedures for specimen collection, processing, etc. in addition to a commercially-viable instrument prototype. Results of this work enable translation of the technology from academic lab to physicians’ office. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|