The Photosensitizing Efficacy of Micelles Containing a Porphyrinic Photosensitizer and KI against Resistant Melanoma Cells

Autor:	Kelly A D F Castro, Juliana C. Biazzotto, Letícia D. Costa, Juliana A Prandini, Augusto C. Tomé, Maria da Graça P. M. S. Neves, M. Amparo F. Faustino, Michael R. Hamblin, Roberto Santana da Silva
Rok vydání:	2021
Předmět:	Porphyrins medicine.medical_treatment Photodynamic therapy 010402 general chemistry 01 natural sciences Micelle Article Catalysis chemistry.chemical_compound medicine Humans Photosensitizer Melanoma Micelles Photosensitizing Agents Singlet Oxygen 010405 organic chemistry Chemistry Singlet oxygen Organic Chemistry General Chemistry medicine.disease Antimicrobial Porphyrin 0104 chemical sciences Photochemotherapy Cancer research Alternative strategy
Zdroj:	Chemistry
ISSN:	1521-3765 0947-6539
DOI:	10.1002/chem.202004389
Popis:	Photodynamic therapy (PDT) is a promising alternative to overcome the resistance of melanoma to conventional therapies. Currently applied photosensitizers (PS) are often based on tetrapyrrolic macrocycles like porphyrins. Unfortunately, in some cases the use of this type of derivative is limited due to their poor solubility in the biological environment. Feasible approaches to surpass this drawback are based on lipid formulations. Besides that, and inspired in the efficacy of potassium iodide (KI) for antimicrobial photodynamic therapy (aPDT), the combined effect of singlet oxygen (1 O2 ) with KI was assessed in this work, as an alternative strategy to potentiate the effect of PDT against resistant melanoma cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e2d49bf8c9f4a1ffa8ef892987a9c9 https://doi.org/10.1002/chem.202004389 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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