Cardiometabolic Risk in Chinese Women with Prior Gestational Diabetes: A 15-Year Follow-Up Study
| Autor: | Terence T. Lao, Clive S. Cockram, Wing Hung Tam, Ronald C.W. Ma, G. T. C. Ko, Juliana C.N. Chan, Xilin Yang, Christopher W.K. Lam, Michael Ho-Ming Chan |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
China Pediatrics medicine.medical_specialty Beta-cell Function Cohort Studies Predictive Value of Tests Pregnancy Risk Factors Insulin-Secreting Cells Internal medicine Prevalence Humans Medicine Metabolic Syndrome Cardiometabolic risk business.industry Follow up studies Obstetrics and Gynecology Insulin sensitivity Type 2 Diabetes Mellitus Middle Aged medicine.disease Gestational diabetes Diabetes Gestational Endocrinology Diabetes Mellitus Type 2 Reproductive Medicine Case-Control Studies Hypertension Disease Progression Female Insulin Resistance Metabolic syndrome business Follow-Up Studies |
| Zdroj: | Gynecologic and Obstetric Investigation. 73:168-176 |
| ISSN: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000329339 |
| Popis: | Aims: The progression to type 2 diabetes mellitus (DM) and other long-term cardiometabolic risks in Chinese women with prior history of gestational diabetes (GD) was studied at 15 years postpartum. Methods: 139 Chinese women (45 with GD and 94 with normal glucose tolerance (NGT) at the index pregnancy) who had their insulin sensitivity and β-cell functions examined at 8 years postpartum were again followed up at 15 years for the investigation of the rate of type 2 DM, hypertension and metabolic syndrome. Results: Women with prior history of GD had a significantly higher rate of hypertension (35.6% vs. 16.0%, p = 0.01), type 2 DM (24.4% vs. 5.3%, p < 0.001) and impaired glucose regulation (26.6% vs. 14.9%, p < 0.001) than women with NGT during the index pregnancy. The Matsuda insulin sensitivity index and the quantitative insulin sensitivity check index at 8 years postpartum were independent predictors of both DM and metabolic syndrome at 15 years postpartum. Conclusions: The conversion rate of type 2 DM increased at an average rate of 1.6% per year after a pregnancy affected by GD. Insulin resistance at 8 years postpartum could refine a future diabetic risk in women with prior history of GD. |
| Databáze: | OpenAIRE |
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