Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer

Autor: Ulf Hinz, Markus W. Büchler, Magdalene Herber, Jürgen Weitz, Moritz Koch, Ulrich Bork, Thomas Schmidt, Christine S. Falk, Nuh N. Rahbari
Jazyk: angličtina
Předmět:
Oncology
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Pathology
Cancer Research
Becaplermin
Kaplan-Meier Estimate
lcsh:RC254-282
chemistry.chemical_compound
Surgical oncology
Pancreatic cancer
Internal medicine
Carcinoma
medicine
Genetics
Humans
Angiogenic Proteins
Lymph node
Aged
Proportional Hazards Models
Platelet-Derived Growth Factor
Vascular Endothelial Growth Factor Receptor-1
Epidermal Growth Factor
business.industry
Proportional hazards model
Membrane Proteins
Proto-Oncogene Proteins c-sis
Middle Aged
medicine.disease
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Neoplasm Proteins
Vascular endothelial growth factor
Gene Expression Regulation
Neoplastic
Pancreatic Neoplasms
medicine.anatomical_structure
chemistry
Pancreatitis
Cytokines
CA19-9
Female
Angiotensin I
business
Carcinoma
Pancreatic Ductal
Research Article
Zdroj: BMC Cancer, Vol 11, Iss 1, p 286 (2011)
BMC Cancer
ISSN: 1471-2407
DOI: 10.1186/1471-2407-11-286
Popis: Background The utility of circulating angiogenic cytokines (CAC) as biomarkers in pancreatic cancer has not been clarified yet. We investigated the expression and prognostic associations of seven CAC in patients with pancreatic cancer. Methods Serum samples were collected preoperatively in patients undergoing surgery for localized pancreatic cancer (n = 74), metastatic pancreatic cancer (n = 24) or chronic pancreatitis (n = 20) and in healthy controls (n = 48). Quantitative enzyme-linked immunosorbent assays and multiplex protein arrays were used to determine circulating levels of VEGF, VEGFR-1, PlGF, PDGF-AA, PDGF-BB, Ang-1 and EGF. Multivariate analyses on cancer-specific survival were performed with a Cox proportional hazards model. Results VEGF (p < 0.0001), PDGF-AA (p < 0.0001), Ang-1 (p = 0.002) and EGF (p < 0.0001) were differentially expressed in patients with pancreatic cancer compared to healthy controls. The presence of lymph node metastases was associated with increased levels of all CAC except for PlGF, whereas there were only minor associations of CAC with other clinicopathologic variables. The multivariate model including the entire angiogenic panel revealed high levels of circulating PDGF-AA (hazard ratio 4.58; 95% confidence interval 1.43 - 14.69) as predictor of poor cancer-specific survival, whereas high levels of PDGF-BB (0.15; 0.15 - 0.88), Ang-1 (0.30; 0.10 - 0.93) and VEGF (0.24; 0.09 - 0.57) were associated with a favorable prognosis. Conclusion Circulating levels of certain angiogenic cytokines correlate with patients' prognosis after resection for pancreatic cancer, if a panel of several CAC is considered simultaneously. These data should be considered in future studies evaluating angiogenic factors as prognostic biomarkers and therapeutic targets in patients with pancreatic cancer.
Databáze: OpenAIRE
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