Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer
Autor: | Ulf Hinz, Markus W. Büchler, Magdalene Herber, Jürgen Weitz, Moritz Koch, Ulrich Bork, Thomas Schmidt, Christine S. Falk, Nuh N. Rahbari |
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Jazyk: | angličtina |
Předmět: |
Oncology
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Pathology Cancer Research Becaplermin Kaplan-Meier Estimate lcsh:RC254-282 chemistry.chemical_compound Surgical oncology Pancreatic cancer Internal medicine Carcinoma medicine Genetics Humans Angiogenic Proteins Lymph node Aged Proportional Hazards Models Platelet-Derived Growth Factor Vascular Endothelial Growth Factor Receptor-1 Epidermal Growth Factor business.industry Proportional hazards model Membrane Proteins Proto-Oncogene Proteins c-sis Middle Aged medicine.disease Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Neoplasm Proteins Vascular endothelial growth factor Gene Expression Regulation Neoplastic Pancreatic Neoplasms medicine.anatomical_structure chemistry Pancreatitis Cytokines CA19-9 Female Angiotensin I business Carcinoma Pancreatic Ductal Research Article |
Zdroj: | BMC Cancer, Vol 11, Iss 1, p 286 (2011) BMC Cancer |
ISSN: | 1471-2407 |
DOI: | 10.1186/1471-2407-11-286 |
Popis: | Background The utility of circulating angiogenic cytokines (CAC) as biomarkers in pancreatic cancer has not been clarified yet. We investigated the expression and prognostic associations of seven CAC in patients with pancreatic cancer. Methods Serum samples were collected preoperatively in patients undergoing surgery for localized pancreatic cancer (n = 74), metastatic pancreatic cancer (n = 24) or chronic pancreatitis (n = 20) and in healthy controls (n = 48). Quantitative enzyme-linked immunosorbent assays and multiplex protein arrays were used to determine circulating levels of VEGF, VEGFR-1, PlGF, PDGF-AA, PDGF-BB, Ang-1 and EGF. Multivariate analyses on cancer-specific survival were performed with a Cox proportional hazards model. Results VEGF (p < 0.0001), PDGF-AA (p < 0.0001), Ang-1 (p = 0.002) and EGF (p < 0.0001) were differentially expressed in patients with pancreatic cancer compared to healthy controls. The presence of lymph node metastases was associated with increased levels of all CAC except for PlGF, whereas there were only minor associations of CAC with other clinicopathologic variables. The multivariate model including the entire angiogenic panel revealed high levels of circulating PDGF-AA (hazard ratio 4.58; 95% confidence interval 1.43 - 14.69) as predictor of poor cancer-specific survival, whereas high levels of PDGF-BB (0.15; 0.15 - 0.88), Ang-1 (0.30; 0.10 - 0.93) and VEGF (0.24; 0.09 - 0.57) were associated with a favorable prognosis. Conclusion Circulating levels of certain angiogenic cytokines correlate with patients' prognosis after resection for pancreatic cancer, if a panel of several CAC is considered simultaneously. These data should be considered in future studies evaluating angiogenic factors as prognostic biomarkers and therapeutic targets in patients with pancreatic cancer. |
Databáze: | OpenAIRE |
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