The Kidneys Are Quantitatively More Important than Pancreas and Gut as a Source of Guanidinoacetic Acid for Hepatic Creatine Synthesis in Sow-Reared Yucatan Miniature Piglets
| Autor: | Janet A. Brunton, O Chandani Dinesh, Robert F. Bertolo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Arginine Swine Glycine Medicine (miscellaneous) 030209 endocrinology & metabolism Kidney Creatine Methylation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Citrulline Animals Amino Acids Intestinal Mucosa Pancreas Nutrition and Dietetics Methionine Chemistry nutritional and metabolic diseases Guanidinoacetate N-methyltransferase 030104 developmental biology medicine.anatomical_structure Endocrinology Liver Swine Miniature Female |
| Zdroj: | The Journal of Nutrition. 150:443-449 |
| ISSN: | 0022-3166 |
| Popis: | BACKGROUND Arginine:glycine amidinotransferase, necessary for the conversion of arginine (Arg) to guanidinoacetic acid (GAA), is expressed mainly in kidney and pancreas. The methylation of GAA to creatine (Cre) primarily occurs in the liver. The role of the gut in Cre homeostasis has not been characterized. OBJECTIVE We aimed to quantify the contribution of kidney, pancreas, and gut as sources of GAA for Cre synthesis. METHODS Sow-reared, feed-deprived Yucatan miniature piglets (17-21 d old) were randomly assigned to acute intravenous treatments (expressed in μmol/kg/min) of: 1) Arg (4.8) + methionine (1.4) (Arg/Met), 2) Cre (0.6) with Arg/Met (Cre/Arg/Met), 3) citrulline (4.8) + methionine (1.4) (Cit/Met), or 4) alanine (6.2) (Ala). Suckling piglets were also studied. RESULTS Renal GAA release was higher during Cit/Met compared with all other treatments (53-360% higher; P |
| Databáze: | OpenAIRE |
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