Contribution of the mesolimbic dopamine system in mediating the effects of leptin and ghrelin on feeding
Autor: | Roger A.H. Adan, R. van Zessen, G. van der Plasse |
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Rok vydání: | 2012 |
Předmět: |
Leptin
Anorexia Nervosa media_common.quotation_subject Dopamine Medicine (miscellaneous) Appetite Nucleus accumbens Biology Reward mental disorders medicine Humans Obesity Prefrontal cortex media_common Motivation Nutrition and Dietetics digestive oral and skin physiology Dopaminergic Ventral Tegmental Area Feeding Behavior Ghrelin Ventral tegmental area medicine.anatomical_structure nervous system Energy Metabolism Neuroscience psychological phenomena and processes medicine.drug Signal Transduction |
Zdroj: | The Proceedings of the Nutrition Society. 71(4) |
ISSN: | 1475-2719 |
Popis: | Feeding behaviour is crucial for the survival of an organism and is regulated by different brain circuits. Among these circuits the mesolimbic dopamine (DA) system is implicated in the anticipation and motivation for food rewards. This system consists of the dopaminergic neurons in the ventral tegmental area (VTA), and their projections to different cortico-limbic structures such as the nucleus accumbens and medial prefrontal cortex. While the importance of this system in motivational drive for different rewards, including drugs of abuse, has been clearly established, its role in energy balance remains largely unexplored. Evidence suggests that peripheral hormones such as leptin and ghrelin are involved in the anticipation and motivation for food and this might be partially mediated through their effects on the VTA. Yet, it remains to be determined whether these effects are direct effects of ghrelin and leptin onto VTA DA neurons, and to what extent indirect effects through other brain areas contribute. Elucidation of the role of leptin and ghrelin signalling on VTA DA neurons in relation to disruptions of energy balance might provide important insights into the role of this neural circuit in obesity and anorexia nervosa. |
Databáze: | OpenAIRE |
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