Female Gender as a Risk Factor for Transient Post‐Thyroidectomy Hypocalcemia
| Autor: | Richard J. Payne, Michael P. Hier, Michael Tamilia, Valerie Cote, Noah B. Sands, Martin J. Black |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Time Factors medicine.medical_treatment Graves' disease Hashimoto Disease Young Adult Postoperative Complications Sex Factors Risk Factors medicine Humans Risk factor Young adult Aged Retrospective Studies Aged 80 and over Hypocalcemia business.industry Thyroid Thyroidectomy Retrospective cohort study Middle Aged medicine.disease Graves Disease Surgery medicine.anatomical_structure Otorhinolaryngology Hypoparathyroidism Parathyroid Hormone Calcium Female Complication business |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 145:561-564 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1177/0194599811414511 |
| Popis: | Transient post-thyroidectomy hypocalcemia is a common complication following thyroid surgery. Studies have identified risk factors and possible ways to help predict post-thyroidectomy hypocalcemia with the intent of ultimately limiting its incidence. This study evaluates the role of patient gender as a potential risk factor.A retrospective case series with chart review of 270 consecutive total thyroidectomy patients was conducted.Jewish General Hospital, a McGill University-affiliated hospital in Montreal, Canada.219 women and 51 men were included. Postoperative hypocalcemia was defined as any 1 of the following: total serum calcium 1.90 mmol/L or less, or signs and symptoms of hypocalcemia. The following were evaluated as potential confounding factors in the study: age, menopause, preoperative calcium, parathyroid hormone, magnesium and phosphate levels, presence of carcinoma in the surgical specimen, number of parathyroid glands preserved in situ, thyroid gland volume, and nodule size.Female patients experienced transient postoperative hypocalcemia in 24.7% (54/219) of cases, which was significantly greater than the 11.8% (6/51) incidence detected in men (P.05). This represents a female/male relative risk ratio of 2.1 (confidence interval, 1.0-4.6). There was no significant difference in rates of hypocalcemia between premenopausal and postmenopausal women (22.7% vs 26.6%).These findings suggest that being female is likely a risk factor for transient post-thyroidectomy hypocalcemia. Although this association is statistically significant, its magnitude and clinical relevance are uncertain and may be trivial. Additional research is needed to ascertain the physiologic mechanisms underlying this gender difference. |
| Databáze: | OpenAIRE |
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