Outcomes after radiation therapy for T2N0 /stage II glottic squamous cell carcinoma
| Autor: | Bassem Youssef, Lara Hilal, Georges Farha, Karine A. Al Feghali, Jan S. Lewin, Blaine D. Smith, Apurva A. Thekdi, G. Brandon Gunn, Abdallah S.R. Mohamed, Jack Phan, Ibrahim Abu-Gheida, William H. Morrison, Adam S. Garden, David I. Rosenthal, Clifton D. Fuller |
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| Rok vydání: | 2020 |
| Předmět: |
Larynx
medicine.medical_specialty Multivariate analysis Younger age medicine.medical_treatment Stage ii Independent predictor Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine otorhinolaryngologic diseases medicine Overall survival Humans Retrospective Studies Squamous Cell Carcinoma of Head and Neck business.industry Glottic Squamous Cell Carcinoma Radiation therapy stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Radiotherapy Intensity-Modulated Radiology Radiotherapy Conformal business therapeutics |
| Zdroj: | Head Neck |
| ISSN: | 1097-0347 1043-3074 |
| Popis: | BACKGROUND We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT). METHODS Patients who received definitive RT for T2 glottic SCC from 2000 through 2013 were retrospectively reviewed. RESULTS One hundred and thirteen patients were analyzed (median follow-up time 91 months; 85 patients received three-dimensional conformal radiotherapy [3D-CRT] and 28 received intensity-modulated radiation therapy [IMRT]). Fractionation was conventional (58%) or altered (42%); 20 patients (18%) received concurrent chemotherapy. Five-year local control was 83% for the 3D-CRT vs 81% for the IMRT group (P = .76). The ultimate locoregional control at 5 years was 100% for IMRT vs 91% for 3D-CRT (P = .1). The 5-year overall survival (OS) was 78% for 3D-CRT vs 81% for IMRT (P = .83). On multivariate analysis, younger age was the only independent predictor of improved OS (P = .0002). CONCLUSIONS Oncologic and survival outcomes were excellent for patients with T2N0 glottic cancer. Patients treated with IMRT and 3D-CRT had no statistically significant differences in all investigated endpoints. |
| Databáze: | OpenAIRE |
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