Biofunctional Materials for Directing Vascular Development
| Autor: | Jennifer E. Saik, Melissa K. McHale, Jennifer L. West |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Tissue Engineering Tissue Scaffolds business.industry Growth factor medicine.medical_treatment Neovascularization Physiologic Biomaterial Biocompatible Materials Tubule Formation Cell biology Vascular network Scaffold material Microvessels Animals Humans Intercellular Signaling Peptides and Proteins Medicine Cardiology and Cardiovascular Medicine business Engineered tissue |
| Zdroj: | Current Vascular Pharmacology. 10:331-341 |
| ISSN: | 1570-1611 |
| Popis: | Engineered tissue constructs are inherently limited by their lack of microvascularization. Evidence suggests that combining a scaffold material with cells and their cell-secreted signals instigates tubule formation, and various strategies can be employed to tailor the vascular response. This review focuses on rationally designed materials capable of supporting functional neovessel formation and stabilization. Biomaterial scaffolds and their use as growth factor delivery systems are discussed, as well as other functional enhancement strategies to direct cellular responses for effective formation of a mature vascular network. |
| Databáze: | OpenAIRE |
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