Attenuation of cyclophosphamide-induced neurotoxicity in rat by yellow dye extract from root of Brimstone tree (Morinda lucida)
| Autor: | Toyin L. Akomolafe, Stephen A. Adefegha, Ganiyu Oboh, Abayomi O. Adetuyi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Antioxidant Cyclophosphamide medicine.medical_treatment Toxicology medicine.disease_cause Plant Roots Antioxidants Pathology and Forensic Medicine YELLOW DYE chemistry.chemical_compound Morinda lucida medicine Animals Morinda Rats Wistar chemistry.chemical_classification Reactive oxygen species Traditional medicine Plant Extracts Neurotoxicity Brain Cell Biology General Medicine Malondialdehyde medicine.disease Rats Oxidative Stress chemistry Biochemistry Lipid Peroxidation Oxidative stress Immunosuppressive Agents medicine.drug Phytotherapy |
| Zdroj: | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 64(6) |
| ISSN: | 1618-1433 |
| Popis: | Cyclophosphamide is an anticancer and immunosuppressant drug that induces reactive oxygen species (ROS) production, so causing malondialdehyde (MDA) production, which is toxic to cells. This study therefore sought to assess the antioxidant and the protective effect of dietary inclusion (0.5 and 1.0%) of yellow dye from root of Brimstone tree (used to enhance the sensory quality of foods and in folk medicine) on cyclophosphamide-induced oxidative stress in brain. Wistar strain albino rats were placed on diet containing 0.5 and 1.0% yellow dye preparation from root of Brimstone tree for 14 days. Intraperitoneal administration of cyclophosphamide (75 mg/kg of body weight) 24 h before the termination of the experiment caused a significant (P0.05) increase in the brain malondialdehyde (MDA) content (147.2%) and serum activities of aspartate aminotransferase (AST) (21.7 UI/l), alanine amino-transferase (ALT) (29.6 UI/l), alkaline phosphatase (43.8 UI/l) and total bilirubin (1.7 mg/dl). However, there was a significant decrease (P0.05) in the MDA of content of the brain and serum enzyme activities, in those rats fed diet containing the yellow dye in a dose dependent manner. The inhibition of oxidative stress in brain and serum enzymes and metabolites by the dye could be attributed to its high total phenol content and antioxidant activity as typified by its reducing power, free-radical scavenging ability, Fe(II) chelating ability and inhibition of lipid peroxidation. Therefore, dietary inclusion of the yellow dye from root of Brimstone tree could prevent cyclophosphamide-induced oxidative stress in brain and the associated toxicity to the liver. |
| Databáze: | OpenAIRE |
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