CD34+ fibroblast-like cells in the interstitial infiltrates in glomerulonephritis – an immunohistochemical observation
| Autor: | Florica Gadalean, Cristina Gluhovschi, Elena Potencz, Adrian Gluhovschi, Flaviu Bob, Daniel Cioca, Gheorghe Bozdog, Ligia Petrica, Silvia Velciov, Elena Lazar |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty CD34 Antigens CD34 Inflammation Pathology and Forensic Medicine Glomerulonephritis Membranous nephropathy Antigen Fibrosis Humans Medicine Minimal change disease business.industry General Medicine Fibroblasts medicine.disease Immunohistochemistry Cross-Sectional Studies Disease Progression Female medicine.symptom business |
| Zdroj: | Polish Journal of Pathology. 4:267-271 |
| ISSN: | 1233-9687 |
| Popis: | CD34 cells in the interstitial infiltrates in glomerulonephritis (GN) could be the turn - ing point between regenerative processes and interstitial fibrosis. The aim of our study was to assess the presence of CD34+ cells in the interstitial infiltrates in GN. A cross-sectional study of 33 patients with glomerulonephritis, mean age: 43.3 ±11.31 years, 20 male and 13 female, was conducted. Conventional stains, as well as immunohistochemistry for the CD34 antigen were employed on kidney biopsies. Strength of immunohistochemical reaction was assessed semi-quantitatively. Regarding the percentage of cases with CD34+ cells in the interstitial infiltrates out of 33 patients: cells of interstitial infiltrates were 27.3% positive. The percentage of cases showing CD34+ cells at the level of interstitial infiltrates was: 44.4% in FSGS, 14.3% in membranoproliferative GN, 28.6% in membranous nephropathy, 20% in mesangial proliferative GN, 0% in minimal change disease, and 50% in crescentic GN. With the exception of minimal change disease, CD34+ cells were found in the in - terstitial infiltrates in all histopathological forms of GN. Some of these cells were spin - dle-shaped fibroblast-like cells. As inflammation in the tubulointerstitial compart - ment either resolves or proceeds to fibrosis, aims at reversing this process will benefit from analyses of the interstitial infiltrates harboring CD34+ cells. |
| Databáze: | OpenAIRE |
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