A Cross-Sectional Study of Gastrointestinal Symptoms, Depressive Symptoms and Trait Anxiety in Young Adults
| Autor: | Zorana Kurbalija Novicic, Fanny Söderquist, Per M. Hellström, Mia Ramklint, Annica J. Rasmusson, David Just, Janet L. Cunningham, Mikaela Syk |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal Diseases lcsh:RC435-571 Population Anxiety Severity of Illness Index Psykiatri 03 medical and health sciences Young Adult 0302 clinical medicine Rating scale Internal medicine lcsh:Psychiatry medicine Humans Young adult education Depression (differential diagnoses) Irritable bowel syndrome Psychiatric Status Rating Scales Sweden Psychiatry education.field_of_study Irritable bowel syndromes business.industry Bulimia nervosa Depression Depressive disorder medicine.disease Psychiatry and Mental health Cross-Sectional Studies Anxiety disorder 030211 gastroenterology & hepatology business Body mass index 030217 neurology & neurosurgery Research Article Personality |
| Zdroj: | BMC Psychiatry, Vol 20, Iss 1, Pp 1-10 (2020) BMC Psychiatry |
| DOI: | 10.21203/rs.3.rs-38645/v1 |
| Popis: | Background >Patients with functional gastrointestinal disorders have a high psychiatric co-morbidity. This study aimed to investigate and characterise gastrointestinal symptoms in relation to depressive symptoms and trait anxiety in a well-defined population of young adult psychiatric outpatients and healthy controls. Methods Gastrointestinal symptoms were assessed with the Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome (GSRS-IBS). Depressive symptoms were assessed with the Montgomery-Åsberg Depression Rating Scale- Self assessment (MADRS-S). Trait anxiety was estimated with three of the Swedish universities of Personality (SSP) scales: Somatic trait anxiety, Psychic trait anxiety and Stress susceptibility. Self-ratings were collected from 491 young adult psychiatric outpatients and 85 healthy controls. Gastrointestinal symptom severity was compared between patients with and without current psychotropic medication and controls. Associations between gastrointestinal symptoms, depressive symptoms and trait anxiety were assessed using Spearman’s coefficients and generalized linear models adjusting for possible confounders (sex, body mass index, bulimia nervosa). Results Patients, with and without current psychotropic medication, reported significantly more gastrointestinal symptoms than controls. In the generalized linear models, total MADRS-S score (p p p = 0.002) and Stress susceptibility (p = 0.002) were independent predictors of the total GSRS-IBS score. Further exploratory analysis using unsupervised learning revealed a diverse spectrum of symptoms that clustered into six groups. Conclusion Gastrointestinal symptoms are both highly prevalent and diverse in young adult psychiatric outpatients, regardless of current psychotropic medication. Depressive symptom severity and degree of trait anxiety are independently related to the total gastrointestinal symptom burden. |
| Databáze: | OpenAIRE |
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