Pregnancy outcome after exposure to oral contraceptives during the periconceptional period
| Autor: | Gideon Koren, Jin Hoon Chung, Jae-Hyug Yang, Mi Kyoung Koong, Hyun-Kyong Ahn, Alejandro A Nava-Ocampo, Hyun-Mee Ryu, Jung-Yeol Han, Moon Young Kim, June Seek Choi, M. H. Kim |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Health Toxicology and Mutagenesis medicine.medical_treatment Population Gestational Age Toxicology Motherisk Pregnancy medicine Birth Weight Humans Emergency contraception Abortion Therapeutic education education.field_of_study Korea Obstetrics business.industry Infant Newborn Pregnancy Outcome Abnormalities Drug-Induced Gestational age General Medicine Infant Low Birth Weight Delivery Obstetric medicine.disease Abortion Spontaneous Low birth weight Maternal Exposure Family planning Premature Birth Gestation Female medicine.symptom business Contraceptives Oral |
| Zdroj: | Human & Experimental Toxicology. 27:307-313 |
| ISSN: | 1477-0903 0960-3271 |
| DOI: | 10.1177/0960327108092290 |
| Popis: | To evaluate whether periconceptional exposure to oral contraceptives (OCs) increased adverse pregnancy outcomes, 136 pregnant women taking OCs within the periconceptional period were identified at the Korean Motherisk Program. Of them, 120 pregnant women accepted to participate in their study and were followed up until completion of the pregnancy. A control group of 240 age- and gravidity-matched pregnant women exposed to non-teratogen drugs for at least 1 month before pregnancy was also included. The median gestational age at delivery was 39.1 (27.0–41.0) weeks in the exposed group and 39.3 (27.4–42.0) weeks in the control group ( P = 0.19). In the exposed group, 7.1% of babies were born with low birth weight versus 2.6% in the control group ( P = 0.068). The number of preterm deliveries or babies born large for gestational age did not differ between the two groups. In the exposed group, the rate of birth defects was 3.2% ( n = 3/99) versus 3.6% ( n = 7/193) in the control group ( P = 1.0). There were 15 women who took high doses of progesterone (emergency contraception) and no adverse fetal outcomes were observed. In conclusion, periconceptional exposure to OCs does not appear to increase the risk for adverse pregnancy outcomes. |
| Databáze: | OpenAIRE |
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