Atomoxetine could improve intra-individual variability in drug-naïve adults with attention-deficit/hyperactivity disorder comparably with methylphenidate: A head-to-head randomized clinical trial
| Autor: | Yu-Ju Lin, Susan Shur-Fen Gau, Hsiang-Yuan Lin, Li-Kuang Yang, Shoou-Lian Hwang Gu, Hui-Chun Huang, Hsing-Chang Ni |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Atomoxetine Hydrochloride law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Reaction Time medicine Humans Attention deficit hyperactivity disorder Pharmacology (medical) Pharmacology Adrenergic Uptake Inhibitors Methylphenidate Atomoxetine Neuropsychology Intra individual medicine.disease 030227 psychiatry Psychiatry and Mental health Drug-naïve Attention Deficit Disorder with Hyperactivity Central Nervous System Stimulants Female Psychology 030217 neurology & neurosurgery Clinical psychology medicine.drug Atomoxetine hydrochloride |
| Zdroj: | Journal of Psychopharmacology. 30:459-467 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/0269881116632377 |
| Popis: | Objective: Intra-individual variability in reaction time (IIV-RT) is common in individuals with attention-deficit/hyperactivity disorder (ADHD). It can be improved by stimulants. However, the effects of atomoxetine on IIV-RT are inconclusive. We aimed to investigate the effects of atomoxetine on IIV-RT, and directly compared its efficacy with methylphenidate in adults with ADHD. Methods: An 8–10 week, open-label, head-to-head, randomized clinical trial was conducted in 52 drug-naïve adults with ADHD, who were randomly assigned to two treatment groups: immediate-release methylphenidate ( n=26) thrice daily (10–20 mg per dose) and atomoxetine once daily ( n=26) (0.5–1.2 mg/kg/day). IIV-RT, derived from the Conners’ continuous performance test (CCPT), was represented by the Gaussian (reaction time standard error, RTSE) and ex-Gaussian models (sigma and tau). Other neuropsychological functions, including response errors and mean of reaction time, were also measured. Participants received CCPT assessments at baseline and week 8-10 (60.4±6.3 days). Results: We found comparable improvements in performances of CCPT between the immediate-release methylphenidate- and atomoxetine-treated groups. Both medications significantly improved IIV-RT in terms of reducing tau values with comparable efficacy. In addition, both medications significantly improved inhibitory control by reducing commission errors. Conclusion: Our results provide evidence to support that atomoxetine could improve IIV-RT and inhibitory control, of comparable efficacy with immediate-release methylphenidate, in drug-naïve adults with ADHD. Shared and unique mechanisms underpinning these medication effects on IIV-RT awaits further investigation. |
| Databáze: | OpenAIRE |
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