Cell-bound complement activation products associate with lupus severity in SLE

Autor: Ghalib Bello, Daniel J. Wallace, John Conklin, Sonali Narain, Elena Massarotti, Arthur Weinstein, Roberta Vezza Alexander, Joseph M. Ahearn, Jill P. Buyon, Kenneth C. Kalunian, Amit Saxena, Christopher E Collins, Richard Furie, Cristina Arriens, Chaim Putterman, Anca D. Askanase, Susan Manzi, Tyler O'Malley, Thierry Dervieux, Rosalind Ramsey-Goldman, Judith A. James
Rok vydání: 2020
Předmět:
Male
Erythrocytes
Cell
SLE
Severity of Illness Index
Ethnicity
Lupus Erythematosus
Systemic
2.1 Biological and endogenous factors
Statistical analysis
Aetiology
Complement Activation
B-Lymphocytes
Systemic lupus erythematosus
Multivariable linear regression
medicine.diagnostic_test
Complement C4
Complement C3
General Medicine
Middle Aged
Flow Cytometry
medicine.anatomical_structure
Female
Immunosuppressive Agents
lcsh:Immunologic diseases. Allergy
Adult
medicine.medical_specialty
Adolescent
Immunology
Lupus
Brief Communication
Autoimmune Disease
Flow cytometry
Young Adult
Clinical Research
Internal medicine
medicine
Humans
autoimmune diseases
Lupus Erythematosus
business.industry
Inflammatory and immune system
Systemic
medicine.disease
Rheumatology
Complement system
Cross-Sectional Studies
Case-Control Studies
lcsh:RC581-607
Low Complement
business
disease activity
Zdroj: Lupus science & medicine, vol 7, iss 1
Lupus Science & Medicine
Lupus Science and Medicine, Vol 7, Iss 1 (2020)
ISSN: 2053-8790
Popis: ObjectivesTo evaluate the association between lupus severity and cell-bound complement activation products (CB-CAPs) or low complement proteins C3 and C4.MethodsAll subjects (n=495) fulfilled the American College of Rheumatology (ACR) classification criteria for SLE. Abnormal CB-CAPs (erythrocyte-bound C4d or B-lymphocyte-bound C4d levels >99th percentile of healthy) and complement proteins C3 and C4 were determined using flow cytometry and turbidimetry, respectively. Lupus severity was estimated using the Lupus Severity Index (LSI). Statistical analysis consisted of multivariable linear regression and groups comparisons.ResultsAbnormal CB-CAPs were more prevalent than low complement values irrespective of LSI levels (62% vs 38%, respectively, p2=0.145).ConclusionAbnormalities in complement activation as measured by CB-CAPs are associated with increased LSI.
Databáze: OpenAIRE
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