Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age
| Autor: | Györgyi Csábi, Montserrat Parrilla-Roure, Cristina Campoy, María Victoria Escolano-Margarit, Berthold Koletzko, Anne M. Molloy, Maria del Carmen Ramirez-Tortosa, Tamás Decsi, Jeannette Beyer, Rosa Ramos |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Docosahexaenoic Acids 030309 nutrition & dietetics Offspring Pregnancy Trimester Third Medicine (miscellaneous) Physiology Prenatal care Placebo Cohort Studies 03 medical and health sciences 0302 clinical medicine Child Development Cognition Fish Oils Folic Acid Pregnancy medicine Humans 030212 general & internal medicine Child Infant Nutritional Physiological Phenomena Tetrahydrofolates chemistry.chemical_classification 0303 health sciences Nutrition and Dietetics Arachidonic Acid business.industry Infant Maternal Nutritional Physiological Phenomena Fish oil medicine.disease Eicosapentaenoic acid 3. Good health chemistry Eicosapentaenoic Acid Docosahexaenoic acid Dietary Supplements Female business Polyunsaturated fatty acid Follow-Up Studies |
| Zdroj: | American Journal of Clinical Nutrition |
| ISSN: | 1938-3207 |
| Popis: | Background: The influence of prenatal long-chain polyunsaturated fatty acids (LC-PUFAs) and folate on neurologic development remains controversial. Objective: The objective was to assess the long-term effects of n23 (omega-3) LC-PUFA supplementation, 5-methyltetrahydrofolate (5-MTHF) supplementation, or both in pregnant women on cognitive development of offspring at 6.5 y of age. Design: This was a follow-up study of the NUHEAL (Nutraceuticals for a Healthier Life) cohort. Healthy pregnant women in 3 European centers were randomly assigned to 4 intervention groups. From the 20th week of pregnancy until delivery, they received a daily supplement of 500 mg docosahexaenoic acid (DHA) + 150 mg eicosapentaenoic acid [fish oil (FO)], 400 lg 5-MTHF, or both or a placebo. Infants received formula containing 0.5% DHA and 0.4% arachidonic acid (AA) if they were born to mothers receiving FO supplements or were virtually free of DHA and AA until the age of 6 mo if they belonged to the groups that were not supplemented with FO. Fatty acids and folate concentrations were determined in maternal blood at weeks 20 and 30 of pregnancy, at delivery, and in cord blood. Cognitive function was assessed at 6.5 y of age with the Kaufman Assessment Battery for Children (K-ABC). Results: We observed no significant differences in K-ABC scores between intervention groups. Higher DHA in maternal erythrocytes at delivery was associated with a Mental Processing Composite Score higher than the 50th percentile in the offspring. Conclusion: We observed no significant effect of supplementation on the cognitive function of children, but maternal DHA status may be related to later cognitive function in children. This trial was registered at clinicaltrials.gov as NCT01180933. Am J Clin Nutr 2011;94(suppl):1880S‐8S. |
| Databáze: | OpenAIRE |
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