Evidence for the role of 34-kDa galactoside-binding lectin in transformation and metastasis
| Autor: | Victor Hogan, Daguang Zhu, Avraham Raz, Nipa Shah, Pnina Carmi, Rivka Karkash, Tirza Raz, Galit Pazerini |
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| Rok vydání: | 1990 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Fibrosarcoma Galectins Biology Transfection Metastasis Malignant transformation Mice In vivo Tumor Cells Cultured medicine Animals Neoplasm Metastasis DNA Fibroblasts medicine.disease Recombinant Proteins In vitro Transformation (genetics) Cell Transformation Neoplastic Hemagglutinins Oncology Galactoside binding Cancer research Cell Division |
| Zdroj: | International Journal of Cancer. 46:871-877 |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | The endogenous M, 34,000 galaictoside-binding lectin (L-34) is found at elevated levels in a wilde variety of neoplastic cells and correlative evidence suggests that it is involved in tumor metastasis in vivo and in transformation in vitro. We demonstrate here that introduction of recombinant L-34 into tumorigenic, weakly metastatic UV-2237-cl- I 5 fibrosarcoma cells results in an increased incidence of experimental lung metastases in syngeneic and nude mice. Transfection of normal BALB/c-A3 I cloned fibroblasts with functional L-34 results in acquisition of anchorage-independent growth and in morphological transformation in vitro but not in tumorigenicity in vivo. These results provide direct evidence that the cellular expression of L-34 is associated with some aspects of transformation and with metastasis, but not with tumorigenicity per se. |
| Databáze: | OpenAIRE |
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