Calcium in pig livers following ischemia and reperfusion
| Autor: | Teruhisa Nakamura, Takeo Kimoto, Yoshinari Takemoto, Dipok Kumar Dhar, Masaaki Uchida, Naofumi Nagasue |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Swine Portal vein Ischemia chemistry.chemical_element Portacaval shunt Calcium Dry weight Malondialdehyde Internal medicine Animals Medicine Aspartate Aminotransferases Analysis of Variance Hepatology business.industry medicine.disease Surgery Survival Rate Endocrinology medicine.anatomical_structure Liver chemistry Reperfusion Injury Calcium concentration Female Lipid Peroxidation business Artery |
| Zdroj: | Journal of Hepatology. 20:714-719 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/s0168-8278(05)80140-0 |
| Popis: | Calcium concentrations in pig livers were serially estimated following ischemia-reperfusion. Ischemia was produced by clamping the hepatic artery and the portal vein for 90 min (Group 1, n = 6) or for 180 min (Group 2, n = 6) during temporary side-to-side portacaval shunt performed before the induction of ischemia. Although there were no significant changes in hepatic calcium concentrations during ischemia, an immediate accumulation of calcium occurred 30 min after reperfusion in both groups. After these increases, the hepatic calcium concentration decreased to near the pre-ischemic level within 20 min in all animals in Group 1. The recovery of calcium was incomplete in Group 2. When the peak was defined as the highest level of calcium and the bottom as the lowest point after peak 60 min after reperfusion, the mean-peak was 11.0 +/- 1.3 (mean +/- SEM) nmol/mg dry weight liver in Group 1 and 12.8 +/- 1.4 nmol/mg dry weight liver in Group 2 (not significant). However, the mean-bottom in Group 1 was lower than that in Group 2 (5.5 +/- 0.3 and 8.1 +/- 0.8 nmol/mg dry weight liver, respectively, p0.05). These results indicate that hepatic calcium increases immediately after reperfusion and that recovery from this calcium accumulation seems to be a crucial factor for minimizing cellular injury. |
| Databáze: | OpenAIRE |
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