How Cryptococcus interacts with the blood-brain barrier
| Autor: | Tseng-Yu Huang, Ambrose Jong, Alice Ying-Jung Wu, Hsin-Hong Chen, Hsiang-Kuang Tseng, Chang-Pan Liu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Pathology medicine.medical_specialty Cryptococcus Blood–brain barrier Microbiology Ammonia medicine Humans Fibrinolysin biology Tight junction Microvesicle Macrophages Brain Endothelial Cells Human brain Cryptococcosis biology.organism_classification medicine.disease Microvesicles Cell biology Endothelial stem cell medicine.anatomical_structure Hyaluronan Receptors Blood-Brain Barrier |
| Zdroj: | Future microbiology. 10(10) |
| ISSN: | 1746-0921 |
| Popis: | Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by which Cryptococcus crosses the blood–brain barrier (BBB) to cause brain invasion is largely unknown. In order for Cryptococcus to cross the BBB, there must be a way to either cross human brain microvascular endothelial cells, which are the main constitute of the BBB, or go in between tight junctions. Recent evidence of human brain microvascular endothelial cell responses to transcellular brain invasions includes membrane rearrangements, intracellular signaling pathways and cytoskeletal activations. Several Cryptococcal genes related to the traversal of BBB have been identified, including CPS1, ITR1a, ITR3c, PLB1, MPR1, FNX1 and RUB1. In addition, Cryptococcus neoformans-derived microvesicles may contribute to cryptococcal brain invasion. Paracellularly, Cryptococcus may traverse across BBB using either routes utilizing plasmin, ammonia or macrophages in a Trojan horse mechanism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|