Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12
| Autor: | Jeffrey R. Gulcher, Klaus Lindpaintner, Einar M. Valdimarsson, Gisli Einarsson, Radinka Hadzic, Ramanjit Gill, Finnbogi Jakobsson, Sigrun M. Bjarnadottir, Solveig Gretarsdottir, Herdis M. Gudjonsdottir, Michael L. Frigge, Olafur B. Einarsson, Sif Jonsdottir, Vilmundur Gudnason, Gunnar Th. Sigurdsson, Elisabet Einarsdottir, Helgi H. Hannesson, Gudmundur Thorgeirsson, Jesus Sainz, H. Jonsson, Augustine Kong, Thorunn Gudmundsdottir, Dana Shkolny, Sigridur Th. Reynisdottir, Kari Stefansson, Uggi Agnarsson, Gudrun J. Gudlaugsdottir, Sigurlaug Sveinbjörnsdóttir |
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| Rok vydání: | 2002 |
| Předmět: |
Genetic Markers
Male Hypercholesterolemia Population Iceland Locus (genetics) Pedigree chart Biology Genetic determinism Diabetes Complications 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes Mellitus medicine Genetics Humans Genetic Predisposition to Disease Genetics(clinical) Allele Family history education Stroke Alleles Genetics (clinical) 030304 developmental biology 0303 health sciences education.field_of_study Genome Human Chromosome Mapping Articles medicine.disease Pedigree Genetic marker Hypertension Chromosomes Human Pair 5 Female Lod Score 030217 neurology & neurosurgery |
| Zdroj: | The American Journal of Human Genetics. 70(3):593-603 |
| ISSN: | 0002-9297 |
| DOI: | 10.1086/339252 |
| Popis: | Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P =3.9×10 −6 ). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as " STRK1, " does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke. |
| Databáze: | OpenAIRE |
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