Effect of Euterpe oleracea Mart. Seeds Extract on Chronic Ischemic Renal Injury in Renovascular Hypertensive Rats
| Autor: | Cristiane Aguiar da Costa, Letícia Lopes de Melo Cunha, Lenize Costa Reis Marins de Carvalho, Angela Castro Resende, Dayane Teixeira Ognibene, Izabelle Barcellos Santos, Roberto Soares de Moura, Graziele Freitas de Bem, Viviane da Silva Cristino Cordeiro, Ricardo de Andrade Soares |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty animal structures Antioxidant Euterpe Urinary system medicine.medical_treatment Medicine (miscellaneous) Blood Pressure 030204 cardiovascular system & hematology Protein oxidation medicine.disease_cause Kidney Renovascular hypertension 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Humans Rats Wistar Antihypertensive Agents chemistry.chemical_classification Creatinine Nutrition and Dietetics business.industry Plant Extracts Superoxide Dismutase Glutathione peroxidase medicine.disease Catalase Rats Oxidative Stress 030104 developmental biology medicine.anatomical_structure Endocrinology Hypertension Renovascular chemistry Seeds business Oxidative stress |
| Zdroj: | Journal of medicinal food. 20(10) |
| ISSN: | 1557-7600 |
| Popis: | Previously, we have demonstrated that the seeds of Euterpe oleracia Mart. (acai) are rich in polyphenols with antihypertensive and antioxidant properties. This study evaluated the renal protective effects of the hydroalcoholic extract obtained from the seeds of acai (ASE) fruits in two-kidney, one-clip (2K1C) renovascular hypertension. Young male Wistar rats were used to obtain 2K1C and sham groups. Animals received ASE (200 mg/(kg·day) in drinking water) or vehicle for 40 days. We evaluated serum and urinary parameters, renal structural changes, and oxidative status. The increase in systolic blood pressure of the 2K1C group was accompanied by a decrease in left kidney volume and number of glomeruli, as well as an increase in glomerular volume and collagen deposition. ASE prevented the alterations of these parameters, except the reduced kidney volume. Serum levels of urea and creatinine and urinary protein excretion were increased in the 2K1C group and treatment with ASE improved all these functional parameters. The increased oxidative damage in the 2K1C group, assessed by lipid and protein oxidation, was prevented by ASE. The nitrite content and both expression and activity of antioxidant enzymes (superoxide dismutase-1, catalase, and glutathione peroxidase) were lower in the 2K1C group and restored by ASE. ASE substantially reduced renal injury and prevented renal dysfunction in 2K1C rats probably through its antihypertensive and antioxidant effects, providing a natural resource for treatment and prevention of renovascular hypertension-related abnormalities. |
| Databáze: | OpenAIRE |
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