A carbon nanotubes based in situ multifunctional power assist system for restoring failed heart function
| Autor: | Tai-Zhong Chen, Qing Zhou, Yuli Yang, Yudong Fei, Wei Li, Quanfu Xu, Qian Wang, Jing Ren, Jian-Wen Hou, Yi-Gang Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cultural Studies
Linguistics and Language History Materials science lcsh:Medical technology Cardiac pacing lcsh:Biotechnology Diastole Carbon nanotubes Heart failure 02 engineering and technology Carbon nanotube 030204 cardiovascular system & hematology Language and Linguistics law.invention 03 medical and health sciences 0302 clinical medicine Tissue engineering law lcsh:TP248.13-248.65 medicine Power assist device Rabbit heart 021001 nanoscience & nanotechnology medicine.disease Structure and function Power (physics) Aligned materials lcsh:R855-855.5 Anthropology 0210 nano-technology Research Article Biomedical engineering |
| Zdroj: | BMC Biomedical Engineering, Vol 3, Iss 1, Pp 1-13 (2021) BMC Biomedical Engineering |
| ISSN: | 2524-4426 |
| Popis: | Background End-stage heart failure is a major risk of mortality. The conductive super-aligned carbon nanotubes sheets (SA-CNTs) has been applied to restore the structure and function of injured myocardium through tissue engineering, and developed as efficient cardiac pacing electrodes. However, the interfacial interaction between SA-CNTs and the surface cells is unclear, and it remains challenge to restore the diminished contraction for a seriously damaged heart. Results A concept of a multifunctional power assist system (MPS) capable of multipoint pacing and contraction assisting is proposed. This device is designed to work with the host heart and does not contact blood, thus avoiding long-term anticoagulation required in current therapies. Pacing electrode constructed by SA-CNTs promotes the epithelial-mesenchymal transition and directs the migration of pro-regenerative epicardial cells. Meanwhile, the power assist unit reveals an excellent frequency response to alternating voltage, with natural heart mimicked systolic/diastolic amplitudes. Moreover, this system exhibits an excellent pacing when attached to the surface of a rabbit heart, and presents nice biocompatibility in both in vitro and in vivo evaluation. Conclusions This MPS provides a promising non-blood contact strategy to restore in situ the normal blood-pumping function of a failed heart. |
| Databáze: | OpenAIRE |
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