Diffusion-MRI in neurodegenerative disorders
| Autor: | Joseph Goveas a, Laurence O'Dwyer b, Mario Mascalchi c, d, Mirco Cosottini e, f, Stefano Diciotti g, Silvia De Santis h, Luca Passamonti i, Carlo Tessa j, Nicola Toschi k, l, m, Marco Giannelli n |
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| Přispěvatelé: | Goveas, Joseph, O'Dwyer, Laurence, Mascalchi, Mario, Cosottini, Mirco, Diciotti, Stefano, De Santis, Silvia, Passamonti, Luca, Tessa, Carlo, Toschi, Nicola, Giannelli, Marco |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
Radiology Nuclear Medicine and Imaging Parkinson's disease Diffusion-MRI Contrast Media Disease Nuclear Medicine and Imaging Degenerative ataxias Amyotrophic lateral sclerosis Alzheimer's disease DTI Huntington's disease medicine.diagnostic_test diffusion Brain Settore MED/37 - Neuroradiologia Neurodegenerative Diseases neurodegenerative disorders Settore MED/26 - Neurologia Radiology Alzheimer’s disease Algorithms MRI Huntington’s disease medicine.medical_specialty Biophysics ataxias Biomedical Engineering Sensitivity and Specificity Settore MED/36 - Diagnostica per Immagini e Radioterapia Degenerative ataxia Image Interpretation Computer-Assisted medicine Humans Amyotrophic lateral sclerosi Mechanism (biology) business.industry Reproducibility of Results Magnetic resonance imaging Parkinson’s disease medicine.disease Image Enhancement Settore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin) Review article Diffusion Magnetic Resonance Imaging Biophysic business Neuroscience Diffusion MRI |
| Zdroj: | Magnetic resonance imaging 33 (2015): 853–876. doi:10.1016/j.mri.2015.04.006 info:cnr-pdr/source/autori:Joseph Goveas a, Laurence O'Dwyer b, Mario Mascalchi c,d, Mirco Cosottini e,f, Stefano Diciotti g, Silvia De Santis h, Luca Passamonti i, Carlo Tessa j, Nicola Toschi k,l,m, Marco Giannelli n/titolo:Diffusion-MRI in neurodegenerative disorders./doi:10.1016%2Fj.mri.2015.04.006/rivista:Magnetic resonance imaging/anno:2015/pagina_da:853/pagina_a:876/intervallo_pagine:853–876/volume:33 |
| Popis: | The ability to image the whole brain through ever more subtle and specific methods/contrasts has come to play a key role in understanding the basis of brain abnormalities in several diseases. In magnetic resonance imaging (MRI), “diffusion” (i.e. the random, thermally-induced displacements of water molecules over time) represents an extraordinarily sensitive contrast mechanism, and the exquisite structural detail it affords has proven useful in a vast number of clinical as well as research applications. Since diffusion-MRI is a truly quantitative imaging technique, the indices it provides can serve as potential imaging biomarkers which could allow early detection of pathological alterations as well as tracking and possibly predicting subtle changes in follow-up examinations and clinical trials. Accordingly, diffusion-MRI has proven useful in obtaining information to better understand the microstructural changes and neurophysiological mechanisms underlying various neurodegenerative disorders. In this review article, we summarize and explore the main applications, findings, perspectives as well as challenges and future research of diffusion-MRI in various neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease and degenerative ataxias. |
| Databáze: | OpenAIRE |
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