Pharmacokinetic and immunosuppressive effects of tacrolimus-loaded biodegradable microspheres
| Autor: | Takeji Uno, Yoshiaki Kawashima, Hideo Kawarasaki, Koh-ichi Sakamoto, Li Xiao-Kang, Hirofumi Takenaka, Hiromitsu Yamamoto, Hisakuni Hashimoto, Yasunori Miyamoto |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Dose Injections Subcutaneous medicine.medical_treatment Pharmacology Liver transplantation Tacrolimus Drug Delivery Systems Pharmacokinetics Animals Medicine Transplantation Dose-Response Relationship Drug Hepatology business.industry Immunosuppression Microspheres Liver Transplantation Rats Dose–response relationship Surgery Lymph Nodes Lymph business Immunosuppressive Agents |
| Zdroj: | Liver Transplantation. 10:392-396 |
| ISSN: | 1527-6473 1527-6465 |
| Popis: | The objective of this study was to characterize the pharmacokinetics and immunosuppression of a tacrolimus-loaded biodegradable microsphere (TLBM) in rats. We prepared TLBM. DA/Slc rats were given TLBM at a dose of 1.6 mg/kg (n = 9), 2.4 mg/kg (n = 5), or 7.2 mg/kg (n = 7) tacrolimus contents by a single subcutaneous administration to achieve sustained release over a long period. DA/Slc rats were given TLBM by a single subcutaneous administration at a dose of 4.8 mg/kg (n = 6) tacrolimus contents to clarify the main site of TLBM uptake in the organs. In the rat liver transplantation model, the recipients were given TLBM at a dose of 0.16 mg/kg (n = 5), 2.4 mg/kg (n = 4), or 4.8 mg/kg (n = 5) tacrolimus contents by a single subcutaneous administration on the first day after operation. Overall survival days were compared. Continuous flat parallel concentration profiles were significant for 10 days from the first day after a single subcutaneous administration of TLBM (P |
| Databáze: | OpenAIRE |
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