Galectin 3: an extraordinary multifunctional protein in dermatology. Current knowledge and perspectives
Autor: | Christina Papadionysiou, Alexandra Monastirli, Efstathia Pasmatzi, George Badavanis, Dionysios Tsambaos |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Galectin 3
Galectins Carbohydrates Amino Sugars Dermatitis General Medicine Blood Proteins Review Dermatology Biology Human cell Cutaneous Disorders 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Galectin-3 030220 oncology & carcinogenesis RL1-803 Myeloid cells otorhinolaryngologic diseases Humans Epidermis Neuroscience Galectin |
Zdroj: | Anais Brasileiros de Dermatologia, Vol 94, Iss 3, Pp 348-354 (2019) Anais Brasileiros de Dermatologia v.94 n.3 2019 Anais brasileiros de dermatologia Sociedade Brasileira de Dermatologia (SBD) instacron:SBD Anais Brasileiros de Dermatologia Anais Brasileiros de Dermatologia, Volume: 94, Issue: 3, Pages: 348-354, Published: 29 JUL 2019 |
ISSN: | 0365-0596 |
Popis: | Galectin 3 is a unique ~31 kDa protein that recognizes the N-acetyl-lactosamine structure of several glycoconjugates. It mainly occurs in epithelial and myeloid cells, but is also found in a variety of human cell types. In view of the crucial role played by galectin 3 in the regulation of cellular processes of essential importance and in the pathogenetic mechanisms of diverse disorders, it is not surprising that, particularly in the last three decades, the attention of the scientific community has been increasingly drawn to this extraordinary and multifunctional galectin. In this paper the authors summarize current knowledge on the expression of galectin 3 in normal and diseased human skin, its implications in the pathogenesis, diagnosis and prognosis of cutaneous disorders, and the perspectives of a novel approach to the treatment of the latter using galectin 3 or its inhibitors/antagonists. |
Databáze: | OpenAIRE |
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