Neural correlates of malingering in mild traumatic brain injury: A positron emission tomography study
| Autor: | Andrea D. Spadoni, Alan N. Simmons, Elena Kosheleva, Monte S. Buchsbaum |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Malingering medicine.medical_specialty Traumatic brain injury Neuroscience (miscellaneous) Ventromedial prefrontal cortex Prefrontal Cortex Neuropsychological Tests Audiology Young Adult Neuroimaging Test of Memory Malingering medicine Humans Radiology Nuclear Medicine and imaging Effects of sleep deprivation on cognitive performance Psychiatry Iraq War 2003-2011 Brain Concussion Veterans Fluorodeoxyglucose medicine.diagnostic_test medicine.disease Psychiatry and Mental health medicine.anatomical_structure Positron emission tomography Brain Injuries Positron-Emission Tomography Nerve Net Psychology medicine.drug |
| Zdroj: | Psychiatry Research: Neuroimaging. 233:367-372 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2015.06.007 |
| Popis: | The detection of malingering in cognitive performance is a challenge in clinical and legal environments. Neuroimaging may provide an objective method to determine the source of failure on tests of symptom validity. Participants comprised 45 combat veterans, 31 with mild traumatic brain injury (mTBI), not seeking medical or legal compensation, who completed the Tombaugh Test of Memory Malingering (TOMM) and a positron emission tomography (PET) scan. Based on TOMM performance (i.e., less than 45 of 50 total correct, suggesting suboptimal effort or malingering), subjects were separated into poor TOMM score (PT; n=10) and good TOMM score (GT; n=35) groups. Voxel-based multiple regression analysis with Group (GT/PT) predicting uptake of fluorodeoxyglucose revealed decreased brain metabolism in the ventromedial prefrontal cortex of poor performers. The current findings may suggest that poor TOMM performance in those with combat trauma and mTBI may be related to ventromedial prefrontal cortical dysfunction. These findings have important implications for the disentanglement of feigned versus actual memory impairment, where the latter may be secondary to neural mechanisms not consistent with forgetting or deception. |
| Databáze: | OpenAIRE |
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