Pure flat epithelial atypia: Is there a place for routine surgery?
| Autor: | Sophie Taïeb, Y.-M. Robin, C. Chaveron, M.-P. Chauvet, Luc Ceugnart, F. Bachelle, H. Jarraya, G. Pouliquen, N. Rocourt, V. Doualliez |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Breast Neoplasms Mastectomy Segmental Diagnosis Differential Lesion Breast cancer Flat Epithelial Atypia Biopsy medicine Humans Genetic Predisposition to Disease Radiology Nuclear Medicine and imaging In patient Breast Borderline lesions Family history Aged Interventional Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Calcinosis Epithelial Cells Histology General Medicine Middle Aged Prognosis medicine.disease Surgery Carcinoma Intraductal Noninfiltrating Radiological weapon Female Biopsy Large-Core Needle medicine.symptom business Precancerous Conditions Carcinoma in Situ Follow-Up Studies Mammography |
| Zdroj: | Diagnostic and Interventional Imaging. 94:861-869 |
| ISSN: | 2211-5684 |
| DOI: | 10.1016/j.diii.2013.01.011 |
| Popis: | Purpose To determine whether it is appropriate to routinely undertake surgery if flat epithelial atypia (FEA) or pure flat epithelial atypia (pFEA) is found on large-core biopsy. Patients and methods Between 2005 and 2010, 1678 large-core biopsy procedures were carried out, which led to 136 FEA sites being identified, 63 of which across 59 patients were pFEA (four patients had two sites of pFEA each). Forty-eight patients underwent further surgical excision, equating to 52 excised sites of pFEA. Results Of the 52 operated sites, there were 20 benign lesions (38%), 26 borderline lesions (56%), and three ductal carcinomas in situ (6%). The rate of histologic underestimation was put at 3.8%. Of the three cases that were underestimated, one was discarded because the definitive histology was not representative of the site from which microcalcifications had initially been taken. The other two cases that were underestimated were found in patients with an increased individual risk of breast cancer. Conclusion In patients with no personal or first-degree family history of breast cancer, after complete or subtotal excision under radiology of the radiological lesion, and while excluding images fitting BI-RADS 5, annual monitoring may be offered as an alternative to surgical excision in view of the absence of underestimation found in our study. |
| Databáze: | OpenAIRE |
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