Possible future monoclonal antibody (mAb)-based therapy against arbovirus infections
| Autor: | Nicasio Mancini, Roberto Burioni, Giuseppe A. Sautto, Giacomo Gorini, Massimo Clementi |
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| Přispěvatelé: | Giuseppe, Sautto, Mancini, Nicasio, Giacomo, Gorini, Clementi, Massimo, Burioni, Roberto |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
General Immunology and Microbiology
Arbovirus Infections medicine.drug_class Passive Immunotherapy lcsh:R Outbreak lcsh:Medicine Antibodies Monoclonal General Medicine Review Article Biology Monoclonal antibody Antibodies Viral Virology General Biochemistry Genetics and Molecular Biology Therapeutic approach In vivo Immunology medicine Effective treatment Animals Humans |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2013 (2013) |
| Popis: | More than 150 arboviruses belonging to different families are known to infect humans, causing endemic infections as well as epidemic outbreaks. Effective vaccines to limit the occurrence of some of these infections have been licensed, while for the others several new immunogens are under development mostly for their improvements concerning safety and effectiveness profiles. On the other hand, specific and effective antiviral drugs are not yet available, posing an urgent medical need in particular for emergency cases. Neutralizing monoclonal antibodies (mAbs) have been demonstrated to be effective in the treatment of several infectious diseases as well as in preliminaryin vitroandin vivomodels of arbovirus-related infections. Given their specific antiviral activity as well-tolerated molecules with limited side effects, mAbs could represent a new therapeutic approach for the development of an effective treatment, as well as useful tools in the study of the host-virus interplay and in the development of more effective immunogens. However, before their use as candidate therapeutics, possible hurdles (e.g., Ab-dependent enhancement of infection, occurrence of viral escape variants) must be carefully evaluated. In this review are described the main arboviruses infecting humans and candidate mAbs to be possibly used in a future passive immunotherapy. |
| Databáze: | OpenAIRE |
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