Too much of a good thing: Long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity

Autor: Donald Henderson, Mohammad Habiby Kermany, Alessandra D’Elia, Massimo Ralli, Dalian Ding, Eric C. Bielefeld, Guang-Di Chen, Chiemi Tanaka, Richard Salvi
Rok vydání: 2010
Předmět:
Aging
medicine.medical_specialty
Sodium Salicylate
Otoacoustic Emissions
Spontaneous
Presbycusis
Audiology
Article
Rats
Sprague-Dawley
Tinnitus
chemistry.chemical_compound
Internal medicine
Evoked Potentials
Auditory
Brain Stem
otorhinolaryngologic diseases
medicine
Animals
Prestin
Cochlear Nerve
Sodium salicylate
biology
business.industry
Age Factors
medicine.disease
Rats
Inbred F344
Sensory Systems
Rats
Compound muscle action potential
Disease Models
Animal
Hair Cells
Auditory
Outer
Endocrinology
medicine.anatomical_structure
Auditory brainstem response
Acoustic Stimulation
chemistry
Cochlear Microphonic Potentials
biology.protein
sense organs
Hair cell
medicine.symptom
Acoustic Stimulation
Age Factors
Aging
Animals
Cochlear Microphonic Potentials
Cochlear Nerve
Disease Models
Animal
Evoked Potentials
Auditory
Brain Stem
Hair Cells
Auditory
Outer
Otoacoustic Emissions
Spontaneous
Presbycusis
Rats
Rats
Inbred F344
Rats
Sprague-Dawley
Sodium Salicylate
Tinnitus
Sensory Systems
Cochlear microphonic potential
business
Zdroj: Hearing Research. 265:63-69
ISSN: 0378-5955
DOI: 10.1016/j.heares.2010.02.010
Popis: Aspirin has been extensively used in clinical settings. Its side effects on auditory function, including hearing loss and tinnitus, are considered as temporary. A recent promising finding is that chronic treatment with high-dose salicylate (the active ingredient of aspirin) for several weeks enhances expression of the outer hair cell (OHC) motor protein (prestin), resulting in strengthened OHC electromotility and enhanced distortion product otoacoustic emissions (DPOAE). To follow up on these observations, we carried out two studies, one planned study of age-related hearing loss restoration and a second unrelated study of salicylate-induced tinnitus. Rats of different strains and ages were injected with salicylate at a dose of 200 mg/kg/day for 5 days per week for 3 weeks or at higher dose levels (250-350 mg/kg/day) for 4 days per week for 2 weeks. Unexpectedly, while an enhanced or sustained DPOAE was seen, permanent reductions in the amplitude of the cochlear compound action potential (CAP) and the auditory brainstem response (ABR) were often observed after the chronic salicylate treatment. The mechanisms underlying these unexpected, permanent salicylate-induced reductions in neural activity are discussed.
Databáze: OpenAIRE
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