Role of CD25 expression on prognosis of acute myeloid leukemia: A literature review and meta-analysis

Autor: Qijie Ran, Senhua Song, Xiaojing Luo, Xinhua Zhang, Jingyuan Li, Dehong Xu, Biao Xu
Rok vydání: 2020
Předmět:
Oncology
Epidemiology
Cancer Treatment
Hematologic Cancers and Related Disorders
Mathematical and Statistical Techniques
Spectrum Analysis Techniques
0302 clinical medicine
Medicine and Health Sciences
Medicine
IL-2 receptor
education.field_of_study
Multidisciplinary
Statistics
Hazard ratio
Myeloid leukemia
Hematology
Metaanalysis
Prognosis
Myeloid Leukemia
Flow Cytometry
Gene Expression Regulation
Neoplastic
Leukemia
Myeloid
Acute
Leukemia
Spectrophotometry
030220 oncology & carcinogenesis
Meta-analysis
Physical Sciences
Cytophotometry
Research Article
Acute Myeloid Leukemia
medicine.medical_specialty
Science
Population
Alpha (ethology)
Research and Analysis Methods
Ethnic Epidemiology
Cytogenetics
03 medical and health sciences
Diagnostic Medicine
Internal medicine
Leukemias
Genetics
Humans
Statistical Methods
education
business.industry
Interleukin-2 Receptor alpha Subunit
Cancers and Neoplasms
Biology and Life Sciences
medicine.disease
Confidence interval
business
Mathematics
030215 immunology
Zdroj: PLoS ONE, Vol 15, Iss 7, p e0236124 (2020)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0236124
Popis: The gene expression for interleukin-2 receptor subunit alpha (CD25/IL2RA) is frequently altered in adults with acute myeloid leukemia (AML). Increasing evidence indicates that the elevated expression of CD25 may be correlated with poor survival for AML patients. Thus, we performed this meta-analysis to further evaluate the prognostic value of elevated CD25 in AML. Eligible studies were gathered by searching on PubMed, Web of Science, and Embase. Using the R language 3.6.0 software, Pooled hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) of overall survival (OS) and disease-free survival (DFS)/relapse-free survival (RFS)/event-free survival (EFS) for total and subgroup analyses were calculated to investigate the association of elevated CD25 and outcomes of AML patients. Ten studies with a total of 1640 participants were enrolled in this meta-analysis. Pooled HRs suggested that overexpression of CD25 predicted poor outcomes on both OS (HR = 2.27, 95%CI 1.95–2.64) and DFS/RFS/EFS (HR = 1.77, 95%CI 1.44–2.17) in overall population. Subgroup analyses stratified by ethnicity, AML subtype, cut-off value, statistical methodologies and detection method draw similar results. Our meta-analysis indicates that elevated CD25 expression is a poor prognostic factor for AML patients. Considering limited number of samples, further relevant studies are warranted.
Databáze: OpenAIRE
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