Effects of lighting variability on locomotion in posterior cortical atrophy
| Autor: | Sebastian J. Crutch, Nick Tyler, Dilek Ocal, Derrick Boampong, Kyriaki Mengoudi, Chris Frost, Tatsuto Suzuki, Keir X.X. Yong, Ian McCarthy, Ayako Suzuki, Nikolaos N. Papadosifos, Teresa Poole |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Visual perception posterior cortical atrophy visual perception Task (project management) 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation medicine RC346-429 Research Articles RC952-954.6 Posterior cortical atrophy Alzheimer's disease Confidence interval Outcome (probability) locomotion Psychiatry and Mental health 030104 developmental biology Geriatrics Neurology. Diseases of the nervous system Neurology (clinical) Completion time Spatial extent Psychology 030217 neurology & neurosurgery Research Article dementia |
| Zdroj: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020) Alzheimer's and Dementia: Translational Research and Clinical Interventions Alzheimer's & Dementia : Translational Research & Clinical Interventions |
| ISSN: | 2352-8737 |
| Popis: | Introduction Clinical reports describe patients with Alzheimer's disease (AD) exhibiting atypical adaptive walking responses to the visual environment; however, there is limited empirical investigation of such behaviors or factors modulating their expression. We aim to evaluate effects of lighting‐based interventions and clinical presentation (visual‐ vs memory‐led) on walking function in participants with posterior cortical atrophy (PCA) and typical AD (tAD). Methods Participants with PCA (n = 10), tAD (n = 9), and healthy controls (n = 12) walked to visible target destinations under different lighting conditions within two pilot repeated‐measures design investigations (Experiment 1: 32 trials per participant; Experiment 2: 36 trials per participant). Participants walked to destinations with the floorpath interrupted by shadows varying in spatial extent (Experiment 1: no, medium, high shadow) or with different localized parts of the environment illuminated (Experiment 2: target, middle, or distractor illuminated). The primary study outcome for both experimental tasks was completion time; secondary kinematic outcomes were proportions of steps identified as outliers (Experiment 1) and walking path directness (Experiment 2). Results In Experiment 1, PCA participants overall demonstrated modest reductions in time taken to reach destinations when walking to destinations uninterrupted by shadows compared to high shadow conditions (7.1% reduction [95% confidence interval 2.5, 11.5; P = .003]). Experiment 2 found no evidence of differences in task performance for different localized lighting conditions in PCA participants overall. Neither experiment found evidence of differences in task performance between conditions in tAD or control participants overall. Completion time in both patient groups was longer relative to controls, and longer in PCA relative to tAD groups. Discussion Findings represent a quantitative characterization of a clinical phenomenon involving patients misperceiving shadows, implicating dementia‐related cortico‐visual impairments. Results contribute to evidence‐based design guidelines for dementia‐friendly environments. |
| Databáze: | OpenAIRE |
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