Vagus Nerve Stimulation Amplifies Task-Induced Cerebral Blood Flow Increase
| Autor: | Nobuhito Saito, Seijiro Shimada, Kensuke Kawai, Naoto Kunii, Tomoyuki Koizumi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
near-infrared spectroscopy
medicine.medical_treatment cerebral blood flow Stimulation Neurosciences. Biological psychiatry. Neuropsychiatry rehabilitation Behavioral Neuroscience Epilepsy Neuroplasticity Medicine Biological Psychiatry Original Research Resting state fMRI business.industry vagus nerve stimulation Blood flow medicine.disease Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure Neurology Cerebral blood flow Cerebral cortex Anesthesia epilepsy business Vagus nerve stimulation RC321-571 Neuroscience |
| Zdroj: | Frontiers in Human Neuroscience Frontiers in Human Neuroscience, Vol 15 (2021) |
| ISSN: | 1662-5161 |
| Popis: | BackgroundVagus nerve stimulation (VNS) is an established palliative surgical treatment for refractory epilepsy. Recently, pairing VNS with rehabilitation received growing attention for their joint effect on neural plasticity. However, objective biological measurements proving the interaction between VNS effects and cortical recruitment are lacking. Studies reported that VNS induced little blood flow increase in the cerebral cortex.ObjectiveThis study tested the hypothesis that pairing VNS with a cognitive task amplifies task-induced cerebral blood flow (CBF).MethodsThis study included 21 patients implanted with vagus nerve stimulator to treat refractory epilepsy. Near-infrared spectroscopy (NIRS) with sensors on the forehead measured CBF changes in the frontal cortices in response to VNS. Cerebral blood flow was measured when VNS was delivered during a resting state or a verbal fluency task. We analyzed the VNS effect on CBF in relation to stimulation intensity and clinical responsiveness.ResultsWe observed no CBF change when VNS was delivered during rest, irrespective of stimulation intensity or responsiveness. Cerebral blood flow changed significantly when a verbal fluency task was paired with VNS in a stimulation intensity-dependent manner. Cerebral blood flow changes in the non-responders showed no intensity-dependency.ConclusionOur results could be an important biological proof of the interaction between VNS effects and cortical recruitment, supporting the validity of pairing VNS with rehabilitation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|