Carotid-Femoral Pulse Transit Time Variability Predicted Mortality and Improved Risk Stratification in the Elderly
| Autor: | Peter M. Nilsson, Yan Borné, Chang-Sheng Sheng, Qian-Hui Guo, Margaretha Persson, Yan Li, Ji-Guang Wang, Gunnar Engström, Ming-Xuan Li, Iram Faqir Muhammad, Ren-Zhi Cai, De-Wei An |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Aging medicine.medical_specialty Pulse Wave Analysis Coefficient of variation Blood Pressure Risk Assessment Cohort Studies Vascular Stiffness Risk Factors Internal medicine Internal Medicine medicine Humans Pulse wave velocity Aged Pulse (signal processing) business.industry Pulse Transit Time Prognosis medicine.disease Femoral Artery Survival Rate Carotid Arteries Blood pressure Cardiovascular Diseases Cohort Arterial stiffness Cardiology Female business |
| Zdroj: | Hypertension. 78:1287-1295 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/hypertensionaha.121.17891 |
| Popis: | The carotid-to-femoral pulse wave velocity, determined by pulse transit time (PTT) and distance, is a well-established measure of arterial stiffness and predicts adverse outcomes. However, its predictive value decreases with aging. To explore new risk indicator in the elderly, we investigated if the variation of carotid-to-femoral pulse wave velocity, registered as beat-to-beat variability of carotid-to-femoral PTT (cf-PTT), could predict outcome. Totally 3015 (median age, 72.4 years; 39.6% men) and 1181 (75.6 years; 42.2% men) subjects from communities of Malmö, Sweden, and Shanghai, China, were analyzed, respectively. Continuous pulse waves for 10 seconds were recorded sequentially at carotid and femoral arterial sites with applanation tonometry (SphygmoCor, Atcor, Australia). During a median of 6.6 and 10.2 years, 389 and 427 deaths occurred in the Malmö and Shanghai cohorts, respectively. Each one-SD increase in the log-transformed coefficient of variation of cf-PTT was associated with 24% (95% CI, 13%–37%) and 21% (10%–33%) increased risk for all-cause mortality in the Malmö and Shanghai subjects, and 60% (33%–91%) for cardiovascular mortality in the Malmö subjects. Adding the coefficient of variation of cf-PTT to the models including conventional risk factors and carotid-to-femoral pulse wave velocity significantly ( P |
| Databáze: | OpenAIRE |
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