Prevention of gallstones by Lidan Granule: Insight into underlying mechanisms using a guinea pig model
| Autor: | Ningxia Zhang, Hongying Zhang, Baojun Liu, Meng Yang, Jingcheng Dong, Yijie Du, Weiyi Gong, Xiao Wu, Yan Zhang, Xiaoqiang Liang |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Adrenocorticotropic hormone Biology hypothalamic-pituitary-adrenal axis General Biochemistry Genetics and Molecular Biology Guinea pig 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine General Pharmacology Toxicology and Pharmaceutics pigment gallstones Bile acid Lidan Granule Cholesterol Adrenal gland General Neuroscience Articles General Medicine Gallstones medicine.disease Ursodeoxycholic acid medicine.anatomical_structure Endocrinology chemistry inflammation 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Hypothalamic–pituitary–adrenal axis medicine.drug |
| Zdroj: | Biomedical Reports |
| ISSN: | 2049-9442 2049-9434 |
| Popis: | The aim of the study was to examine the mechanism of action of Lidan Granule (LDG) for the prevention of gallstones using a guinea pig model. One hundred guinea pigs were divided into five groups randomly: control (standard diet and saline), model [lithogenic diet (LD) and saline], LDG-H (LD and 2 g/kg of LDG), LDG-L (LD and 1 g/kg of LDG), and ursodeoxycholic acid (UDCA) (LD and UDCA) as the positive control. At 6 weeks, the rate of gallstone formation and weight of the adrenal gland were recorded and serum levels of inflammatory cytokines were measured. Levels of corticotrophin-releasing hormone (CRH) in the hypothalamus, adrenocorticotropic hormone (ACTH) in the hypophysis, and serum cortisol were determined. Bile components were tested with colorimetry. At 6 weeks, the rate of gallstone formation was significantly decreased in the LDG-H (14.29%) and LDG-L (21.43%) groups compared to the model group (81.25%; P |
| Databáze: | OpenAIRE |
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