Hepatic Perfusion with FUdR Utilizing an Implantable System in Patients with Liver Primary Cancer or Metastatic Cancer Confined to the Liver
| Autor: | Martin S. Blumenreich, Thomas M. Woodcock, J. David Richardson, Janell Seeger |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Carcinoma Hepatocellular Colorectal cancer medicine.medical_treatment Adenocarcinoma Gastroenterology Adenoma Bile Duct Hepatic Artery Floxuridine Laparotomy Internal medicine medicine Humans Infusions Intra-Arterial Infusion Pumps Aged Chemotherapy business.industry Liver Neoplasms Cancer General Medicine Middle Aged medicine.disease digestive system diseases Regimen Oncology Hepatocellular carcinoma Cholecystitis Colorectal Neoplasms business medicine.drug |
| Zdroj: | Cancer Investigation. 7:1-6 |
| ISSN: | 1532-4192 0735-7907 |
| Popis: | Nineteen patients with colorectal adencarcinoma, three with cholangiocarcinoma, two with hepatocellular carcinoma, and one with carcinoid were treated with hepatic artery infusion chemotherapy. An implantable pump system was used to deliver floxuridine (FUdR), starting at 400 mg for 2 weeks with 2 weeks of rest. Eleven of 15 (73%) measurable patients with colorectal carcinoma responded. Of 6 complete responses, 4 were documented by laparotomy, including 1 with choleangiocarcinoma. Toxicity included dyspepsia and elevated liver function tests in all patients, gastric ulcer in 2, cholecystitis in 2, and sclerosing cholangitis in 3. Overall median survival for the colon cancer patients has not been reached at 16 months. Regional disease was controlled in the majority of patients treated with this regimen with acceptable toxicity and good quality of life. |
| Databáze: | OpenAIRE |
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