Learning to Fish with Genetics: A Primer on the Vertebrate Model Danio rerio
| Autor: | Jennifer O. Liang, Nathalia G. Holtzman, Jacqueline K. Morris, M. Kathryn Iovine |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Organogenesis ved/biology.organism_classification_rank.species Danio Vertebrate Biology 03 medical and health sciences 0302 clinical medicine biology.animal Genetics Animals Regeneration Model organism Zebrafish biology ved/biology Regeneration (biology) Vertebrate biology.organism_classification Primer 030104 developmental biology Gene Expression Regulation Embryology Models Animal 030217 neurology & neurosurgery |
| Zdroj: | Genetics. 203:1069-1089 |
| ISSN: | 1943-2631 |
| Popis: | In the last 30 years, the zebrafish has become a widely used model organism for research on vertebrate development and disease. Through a powerful combination of genetics and experimental embryology, significant inroads have been made into the regulation of embryonic axis formation, organogenesis, and the development of neural networks. Research with this model has also expanded into other areas, including the genetic regulation of aging, regeneration, and animal behavior. Zebrafish are a popular model because of the ease with which they can be maintained, their small size and low cost, the ability to obtain hundreds of embryos on a daily basis, and the accessibility, translucency, and rapidity of early developmental stages. This primer describes the swift progress of genetic approaches in zebrafish and highlights recent advances that have led to new insights into vertebrate biology. |
| Databáze: | OpenAIRE |
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