Emergence and modular evolution of a novel motility machinery in bacteria
| Autor: | Tâm Mignot, Francesca Fiegna, Adrien Ducret, Morgane Wartel, Jennifer Luciano, Céline Brochier-Armanet, Rym Agrebi, Anne Valérie Le Gall |
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| Přispěvatelé: | Bioinformatique, phylogénie et génomique évolutive (BPGE), Département PEGASE [LBBE] (PEGASE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2011 |
| Předmět: |
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
Cancer Research Myxococcus xanthus lcsh:QH426-470 Gliding motility Motility Genomics Models Biological Microbiology Motor protein 03 medical and health sciences Phylogenomics Genetics Molecular Biology Biology Genetics (clinical) Ecology Evolution Behavior and Systematics Phylogeny 030304 developmental biology Spores Bacterial 0303 health sciences Evolutionary Biology biology 030306 microbiology Human evolutionary genetics biology.organism_classification Biological Evolution lcsh:Genetics Evolutionary biology Genes Bacterial Function (biology) Locomotion Research Article |
| Zdroj: | PLoS Genetics PLoS Genetics, 7 (9) PLoS Genetics, Vol 7, Iss 9, p e1002268 (2011) PLoS Genetics, Public Library of Science, 2011, 7(9), pp.1409-1418 PLoS Genetics, 2011, 7 (9), pp.1409-1418. ⟨10.1371/journal.pgen.1002268⟩ |
| ISSN: | 1553-7404 1553-7390 |
| Popis: | Bacteria glide across solid surfaces by mechanisms that have remained largely mysterious despite decades of research. In the deltaproteobacterium Myxococcus xanthus, this locomotion allows the formation stress-resistant fruiting bodies where sporulation takes place. However, despite the large number of genes identified as important for gliding, no specific machinery has been identified so far, hampering in-depth investigations. Based on the premise that components of the gliding machinery must have co-evolved and encode both envelope-spanning proteins and a molecular motor, we re-annotated known gliding motility genes and examined their taxonomic distribution, genomic localization, and phylogeny. We successfully delineated three functionally related genetic clusters, which we proved experimentally carry genes encoding the basal gliding machinery in M. xanthus, using genetic and localization techniques. For the first time, this study identifies structural gliding motility genes in the Myxobacteria and opens new perspectives to study the motility mechanism. Furthermore, phylogenomics provide insight into how this machinery emerged from an ancestral conserved core of genes of unknown function that evolved to gliding by the recruitment of functional modules in Myxococcales. Surprisingly, this motility machinery appears to be highly related to a sporulation system, underscoring unsuspected common mechanisms in these apparently distinct morphogenic phenomena. PLoS Genetics, 7 (9) ISSN:1553-7390 ISSN:1553-7404 |
| Databáze: | OpenAIRE |
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