On disruption of fear memory by reconsolidation blockade: evidence from cannabidiol treatment
| Autor: | Leandro J. Bertoglio, Francisco Silveira Guimarães, Reinaldo N. Takahashi, Lucas Gazarini, Cristina A.J. Stern |
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| Rok vydání: | 2012 |
| Předmět: |
AM251
Male MEDICINA BASEADA EM EVIDÊNCIAS medicine.drug_class medicine.medical_treatment Spontaneous recovery Pharmacology Extinction Psychological Random Allocation Receptor Cannabinoid CB1 Memory Conditioning Psychological medicine Animals Cannabidiol Rats Wistar Evidence-Based Medicine Extinction (psychology) Fear Receptor antagonist Blockade Rats Psychiatry and Mental health Anesthesia Memory consolidation Original Article Cannabinoid Psychology medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | The search for reconsolidation blockers may uncover clinically relevant drugs for disrupting memories of significant stressful life experiences, such as those underlying the posttraumatic stress disorder. Considering the safety of systemically administered cannabidiol (CBD), the major non-psychotomimetic component of Cannabis sativa, to animals and humans, the present study sought to investigate whether and how this phytocannabinoid (3–30 mg/kg intraperitoneally; i.p.) could mitigate an established memory, by blockade of its reconsolidation, evaluated in a contextual fear-conditioning paradigm in rats. We report that CBD is able to disrupt 1- and 7-days-old memories when administered immediately, but not 6 h, after their retrieval for 3 min, with the dose of 10 mg/kg being the most effective. This effect persists in either case for at least 1 week, but is prevented when memory reactivation was omitted, or when the cannabinoid type-1 receptors were antagonized selectively with AM251 (1.0 mg/kg). Pretreatment with the serotonin type-1A receptor antagonist WAY100635, however, failed to block CBD effects. These results highlight that recent and older fear memories are equally vulnerable to disruption induced by CBD through reconsolidation blockade, with a consequent long-lasting relief in contextual fear-induced freezing. Importantly, this CBD effect is dependent on memory reactivation, restricted to time window of |
| Databáze: | OpenAIRE |
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