Testis spectroscopy may predict sperm retrieval rate in men with non-obstructive azoospermia undergoing micro-TESE: A pilot study
| Autor: | Gonca Yetkin Yildirim, Nilufer Celik, Cihat Unlu, Alper Başbuğ, Safak Hatirnaz, Sudenaz Celik, Tansu Kucuk, Onder Celik, Aynur Erşahin, Vahit Özener, Neslihan Gürpınar |
|---|---|
| Přispěvatelé: | Acibadem University Dspace |
| Rok vydání: | 2020 |
| Předmět: |
Non obstructive azoospermia
endocrine system lcsh:Medicine sperm retrieval Creatine lcsh:Gynecology and obstetrics micro-TESE 030218 nuclear medicine & medical imaging Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Testis medicine Choline non-obstructive azoospermia lcsh:RG1-991 Original Investigation Azoospermia 030219 obstetrics & reproductive medicine business.industry Micro tese lcsh:R Obstetrics and Gynecology medicine.disease Sperm magnetic resonance spectroscopy Testicular sperm extraction chemistry Sperm Retrieval business |
| Zdroj: | Journal of the Turkish German Gynecological Association Journal of the Turkish-German Gynecological Association, Vol 21, Iss 2, Pp 70-78 (2020) |
| Popis: | Objective To investigate whether prior testis magnetic resonance spectroscopy predicts the success or failure of micro-dissection testicular sperm extraction (micro-TESE) in patients with non-obstructive azoospermia (NOA). Material and methods Nine men with NOA who were scheduled for micro-TESE for the first time, 9 NOA men with a history of previous micro-TESE and 5 fertile men were enrolled. All NOA patients and fertile controls underwent testis spectroscopy. A multi-voxel spectroscopy sequence was used. Testicular signals of choline (Cho), creatine (Cr), myo-inositol (MI), lactate, and lipids were analyzed quantitatively and compared with the results of the micro-TESEs. Results The most prominent peaks were Cho and Cr in the fertile controls and NOA subjects with positive sperm retrieval in the micro-TESE. A high Cho peak was detected in 87% of the NOA men with positive sperm retrieval. NOA men without sperm at the previous micro-TESE showed a marked decrease in Cho and Cr signals. For positive sperm retrieval in micro-TESE, the cut-off value of Cho was 1.46 ppm, the cut-off value of Cr was 1.43 ppm, and the cut-off value of MI was 0.79 ppm. Conclusion Testis spectroscopy can be used as a non-invasive screening method to predict the success or failure of micro-TESE. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|