Follicular fluid concentration of leukaemia inhibitory factor is decreased among women with polycystic ovarian syndrome during assisted reproduction cycles
| Autor: | J.-F. Moreau, Gérard Chaouat, N. Ledee-Bataille, Jean-Luc Taupin, J. Taïeb, G. Laprée-Delage, Sylvie Dubanchet |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty endocrine system diseases medicine.medical_treatment Fertilization in Vitro Biology Leukemia Inhibitory Factor Follicle-stimulating hormone Ovulation Induction Internal medicine Follicular phase medicine Humans Ovarian reserve Progesterone Lymphokines Estradiol Interleukin-6 Osmolar Concentration Rehabilitation Obstetrics and Gynecology Follicular fluid Polycystic ovary Growth Inhibitors Tissue Donors female genital diseases and pregnancy complications Follicular Fluid Treatment Outcome Endocrinology Reproductive Medicine Oocytes Cytokines Female Ovulation induction Luteinizing hormone Infertility Female Leukemia inhibitory factor hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome |
| Zdroj: | Human Reproduction. 16:2073-2078 |
| ISSN: | 1460-2350 0268-1161 |
| Popis: | BACKGROUND: The possibility that a specific cytokine profile could be detected in the ovaries of patients with polycystic ovarian syndrome (PCOS) was investigated. METHOD: Enzyme-linked immunosorbent assay (ELISA) or bioassays were used to assess the concentrations of leukaemia inhibitory factor (LIF), tumour necrosis factor, interleukin 11, gamma interferon, progesterone and oestradiol in follicular fluids from preovulatory follicles collected after ovarian stimulation from 15 PCOS patients, 15 infertile control patients with regular cycles, and 8 oocyte donors. RESULTS: LIF and progesterone concentrations were significantly lower in the follicular fluid of PCOS patients (LIF median: 265 pg/ml) compared with controls (LIF median: 816 pg/ml); LIF and progesterone follicular fluid concentrations were correlated (r = 0.720, P = 0.0001). The LH/FSH ratio was negatively correlated with LIF concentrations (r = - 0.714, P = 0.0075). Although the PCOS and control patients did not differ significantly in age, ovarian reserve or IVF indication, the implantation rate was significantly lower among the women with PCOS (IR = 9 versus 21%, P = < 0.01). CONCLUSION: The specific cytokine profile of the PCOS patients is probably related to the lower implantation rate since follicular fluid LIF appears to function as an embryotrophic agent. |
| Databáze: | OpenAIRE |
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