Pharmacokinetics of Hoasca alkaloids in healthy humans
| Autor: | G.S Brito, Russell E. Poland, Deborah C. Mash, E.O Andrade, Dennis J. McKenna, E.N Andrade, J. C. Callaway, L.P Raymon, Charles S. Grob |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Pharmacology biology Alkaloid Tetrahydroharmine Dimethyltryptamine Context (language use) Ayahuasca biology.organism_classification Banisteriopsis caapi chemistry.chemical_compound Harmaline Alkaloids Harmine chemistry Reference Values Area Under Curve Drug Discovery Hallucinogens Humans Half-Life |
| Zdroj: | Journal of Ethnopharmacology. 65:243-256 |
| ISSN: | 0378-8741 |
| Popis: | N,N-Dimethyltryptamine (DMT), harmine, harmaline and tetrahydroharmine (THH) are the characteristic alkaloids found in Amazonian sacraments known as hoasca, ayahuasca, and yajè. Such beverages are characterized by the presence of these three harmala alkaloids, where harmine and harmaline reversibly inhibit monoamine oxidase A (MAO-A) while tetrahydroharmine weakly inhibits the uptake of serotonin. Together, both actions increase central and peripheral serotonergic activity while facilitating the psychoactivity of DMT. Though the use of such 'teas' has be known to western science for over 100 years, little is known of their pharmacokinetics. In this study, hoasca was prepared and administered in a ceremonial context. All four alkaloids were measured in the tea and in the plasma of 15 volunteers, subsequent to the ingestion of 2 ml hoasca/kg body weight, using gas (GC) and high pressure liquid chromatographic (HPLC) methods. Pharmacokinetic parameters were calculated and peak times of psychoactivity coincided with high alkaloid concentrations, particularly DMT which had an average Tmax of 107.5 +/- 32.5 min. While DMT parameters correlated with those of harmine, THH showed a pharmacokinetic profile relatively independent of harmine's. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect