Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events

Autor:	David C. Hooper, Anthony A. Philippakis, Jessie M. Gaeta, Sinéad B. Chapman, Christopher Tomkins-Tinch, Caroline N. Cusick, Matthew R. Bauer, John A. Branda, Steven K. Reilly, Lawrence C. Madoff, Kim A. Lagerborg, Stephen F. Schaffner, Molly Kemball, Timelia Fink, Bronwyn MacInnis, Melissa Rudy, Damien Slater, Jeremy Luban, Daniel J. Park, Jacob E. Lemieux, Edward T. Ryan, William P. Hanage, Melis N. Anahtar, Andreas Gnirke, Sushma Chaluvadi, Felecia Cerrato, Adrianne Gladden-Young, Katelyn Flowers, James J. O’Connell, Anna Neumann, Tami D. Lieberman, Eric S. Rosenberg, Catherine M. Brown, Cameron Myhrvold, Bennett M. Shaw, Erica Normandin, Katherine C. DeRuff, Katherine J. Siddle, Jason B. Harris, Sarah E Turbett, Glen R. Gallagher, Travis P. Baggett, Christine Loreth, Pardis C. Sabeti, Virginia M. Pierce, Lydia A. Krasilnikova, Sandra Smole, Amber Carter, Maha R. Farhat, Regina C. LaRocque, Meagan Burns, Aaron E. Lin, Gordon Adams
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Genome Viral law.invention Disease Outbreaks 03 medical and health sciences 0302 clinical medicine law Vulnerable population Humans 030212 general & internal medicine Phylogeny Multidisciplinary Phylogenetic tree Extramural SARS-CoV-2 COVID-19 030104 developmental biology Transmission (mechanics) Geography Evolutionary biology Epidemiological Monitoring Skilled Nursing Facility Boston
Zdroj:	Science
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.abe3261
Popis:	Phylogenetics of superspreading One important characteristic of coronavirus epidemiology is the occurrence of superspreading events. These are marked by a disproportionate number of cases originating from often-times asymptomatic individuals. Using a rich sequence dataset from the early stages of the Boston outbreak, Lemieux et al. identified superspreading events in specific settings and analyzed them phylogenetically (see the Perspective by Alizon). Using ancestral trait inference, the authors identified several importation events, further investigated the context and contribution of particular superspreading events to the establishment of local and wider SARS-CoV-2 transmission, and used viral phylogenies to describe sustained transmission. Science , this issue p. eabe3261 ; see also p. 574
Databáze:	OpenAIRE
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